MOG抗体相关疾病伴下丘脑病变伴嗜睡和CSF食欲素减少：一例报告

Q4 Immunology and Microbiology Clinical and Experimental Neuroimmunology Pub Date : 2022-08-25 DOI:10.1111/cen3.12728

Kanako Menjo, Shinji Ashida, Shohei Murata, Eijirou Tanaka, Chihiro Fujii, Masami Tanaka, Keiko Tanaka, Takashi Kanbayashi, Toshiki Mizuno

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摘要

髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）是一种中枢神经系统炎症性疾病。在这里，我们首次报道了一名患有双侧下丘脑病变引起的嗜睡的MOGAD患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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MOG-antibody-associated disorder with hypothalamic lesions associated with hypersomnia and decrease of orexin in CSF: A case report

Background

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an inflammatory disorder of the central nervous system. Here, we are the first to report a MOGAD patient with hypersomnolence caused by bilateral hypothalamic lesions.

Case presentation

The case involved a 51-year-old female patient with MOGAD who showed hypersomnolence. She had been diagnosed with MOGAD at 50 years old and admitted due to the development of optic neuritis and encephalitis while under corticosteroid and immunosuppressant treatment. These were improved after the introduction of intravenous methylprednisolone and plasma exchange. The orexin level in the cerebrospinal fluid (CSF) was decreased to 142.2 pg/mL (<200 pg/mL) upon admission and improved to a normal level (298.3 pg/mL) after immunotherapy. Bilateral hypothalamic lesions and reduction of the orexin level in the CSF were considered associated with hypersomnia.