{"title":"IL36RN突变分析在接受secukinumab治疗的老年广泛性脓疱性银屑病患者中的应用","authors":"Satoko Minakawa MD, PhD, Yasushi Matsuzaki MD, PhD, Soichiro Watanabe MD, PhD, Kazumitsu Sugiura MD, PhD, Daisuke Sawamura MD, PhD","doi":"10.1002/cia2.12318","DOIUrl":null,"url":null,"abstract":"<p>We present a case of Generalized pustular psoriasis (GPP) presented with SARS-CoV-2 infection under the control of secukinumab. Mutation analysis revealed a heterogeneous c.28C>T (p.Arg10X) mutation in IL36RN. Mutation analysis should be considered to enable preparation for biologic therapy to treat intractable flare-ups.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.1000,"publicationDate":"2023-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12318","citationCount":"0","resultStr":"{\"title\":\"The utility of IL36RN mutation analysis in an elderly patient with generalized pustular psoriasis patient treated with secukinumab\",\"authors\":\"Satoko Minakawa MD, PhD, Yasushi Matsuzaki MD, PhD, Soichiro Watanabe MD, PhD, Kazumitsu Sugiura MD, PhD, Daisuke Sawamura MD, PhD\",\"doi\":\"10.1002/cia2.12318\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>We present a case of Generalized pustular psoriasis (GPP) presented with SARS-CoV-2 infection under the control of secukinumab. Mutation analysis revealed a heterogeneous c.28C>T (p.Arg10X) mutation in IL36RN. Mutation analysis should be considered to enable preparation for biologic therapy to treat intractable flare-ups.\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":15543,\"journal\":{\"name\":\"Journal of Cutaneous Immunology and Allergy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2023-08-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12318\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cutaneous Immunology and Allergy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cia2.12318\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cutaneous Immunology and Allergy","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cia2.12318","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ALLERGY","Score":null,"Total":0}
The utility of IL36RN mutation analysis in an elderly patient with generalized pustular psoriasis patient treated with secukinumab
We present a case of Generalized pustular psoriasis (GPP) presented with SARS-CoV-2 infection under the control of secukinumab. Mutation analysis revealed a heterogeneous c.28C>T (p.Arg10X) mutation in IL36RN. Mutation analysis should be considered to enable preparation for biologic therapy to treat intractable flare-ups.
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