R. Galvis, L. V. Madrid, Nicolás F. Ramírez-Vásquez
{"title":"在过渡期内，补充左旋肉碱可降低荷斯坦奶牛肝脏甘油三酯积累","authors":"R. Galvis, L. V. Madrid, Nicolás F. Ramírez-Vásquez","doi":"10.17533/UDEA.RCCP.V32N3A01","DOIUrl":null,"url":null,"abstract":"Background: The increased use of body reserves observed during peripartum leads to higher needs of L-carnitine by cows, which is restrictive under the production conditions of Colombian high tropics. Objective: To evaluate the lipotropic potential of L-carnitine in Holstein dairy cows during the transition period to lactation. Methods: Twenty-one Holstein cows were fed 0, 100, or 200 g/d L-carnitine fumarate from d 260 of gestation to d 20 postpartum. Hepatic triacylglycerides concentration, total carnitine, free carnitine, acylcarnitine, and serum levels of non-esterified fatty acids (NEFA), β-hydroxybutyrate (β-HB) and urea were determined by spectrophotometry. Repeated measures analysis was used to determine the effects of dose, measurement period, and their interactions. Results: Hepatic triglycerides and the different forms of carnitine showed no difference between sampling periods (p>0.05). Hepatic triglycerides concentration was low and decreased in response to 200 g/d L-carnitine fumarate supplementation (p 0,05) entre periodos de muestreo. La concentracion hepatica de trigliceridos fue baja, y mostro una disminucion significativa (p 0,05). A concentracao hepatica de triglicerideos foi baixa e mostrou diminuicao significativa (p<0,05) em resposta a suplementacao com 200 g/d de fumarato de L-carnitina. A diminuicao dos triglicerideos hepaticos pode ser devido a um aumento na oxidacao de acidos graxos. Asuplementacao com L-carnitina aumentou significativamente (p<0,05) a concentracao de ureia no sangue, possivelmente atraves de um mecanismo de estimulacao do ciclo da ureia previamente descrito em outras especies. Conclusao: A suplementacao com L-carnitina diminuiu a concentracao hepatica de triglicerideos, possivelmente devido ao aumento da oxidacao de acidos graxos no figado. Palavras-chave: disturbios metabolicos; fatores lipotropicos; lipidose; L-carnitina; metabolismo lipidico; periparto; vacas leiteiras.","PeriodicalId":49613,"journal":{"name":"Revista Colombiana De Ciencias Pecuarias","volume":" ","pages":""},"PeriodicalIF":0.2000,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"L-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition period\",\"authors\":\"R. Galvis, L. V. Madrid, Nicolás F. Ramírez-Vásquez\",\"doi\":\"10.17533/UDEA.RCCP.V32N3A01\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: The increased use of body reserves observed during peripartum leads to higher needs of L-carnitine by cows, which is restrictive under the production conditions of Colombian high tropics. Objective: To evaluate the lipotropic potential of L-carnitine in Holstein dairy cows during the transition period to lactation. Methods: Twenty-one Holstein cows were fed 0, 100, or 200 g/d L-carnitine fumarate from d 260 of gestation to d 20 postpartum. Hepatic triacylglycerides concentration, total carnitine, free carnitine, acylcarnitine, and serum levels of non-esterified fatty acids (NEFA), β-hydroxybutyrate (β-HB) and urea were determined by spectrophotometry. Repeated measures analysis was used to determine the effects of dose, measurement period, and their interactions. Results: Hepatic triglycerides and the different forms of carnitine showed no difference between sampling periods (p>0.05). Hepatic triglycerides concentration was low and decreased in response to 200 g/d L-carnitine fumarate supplementation (p 0,05) entre periodos de muestreo. La concentracion hepatica de trigliceridos fue baja, y mostro una disminucion significativa (p 0,05). A concentracao hepatica de triglicerideos foi baixa e mostrou diminuicao significativa (p<0,05) em resposta a suplementacao com 200 g/d de fumarato de L-carnitina. A diminuicao dos triglicerideos hepaticos pode ser devido a um aumento na oxidacao de acidos graxos. Asuplementacao com L-carnitina aumentou significativamente (p<0,05) a concentracao de ureia no sangue, possivelmente atraves de um mecanismo de estimulacao do ciclo da ureia previamente descrito em outras especies. Conclusao: A suplementacao com L-carnitina diminuiu a concentracao hepatica de triglicerideos, possivelmente devido ao aumento da oxidacao de acidos graxos no figado. 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L-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition period
Background: The increased use of body reserves observed during peripartum leads to higher needs of L-carnitine by cows, which is restrictive under the production conditions of Colombian high tropics. Objective: To evaluate the lipotropic potential of L-carnitine in Holstein dairy cows during the transition period to lactation. Methods: Twenty-one Holstein cows were fed 0, 100, or 200 g/d L-carnitine fumarate from d 260 of gestation to d 20 postpartum. Hepatic triacylglycerides concentration, total carnitine, free carnitine, acylcarnitine, and serum levels of non-esterified fatty acids (NEFA), β-hydroxybutyrate (β-HB) and urea were determined by spectrophotometry. Repeated measures analysis was used to determine the effects of dose, measurement period, and their interactions. Results: Hepatic triglycerides and the different forms of carnitine showed no difference between sampling periods (p>0.05). Hepatic triglycerides concentration was low and decreased in response to 200 g/d L-carnitine fumarate supplementation (p 0,05) entre periodos de muestreo. La concentracion hepatica de trigliceridos fue baja, y mostro una disminucion significativa (p 0,05). A concentracao hepatica de triglicerideos foi baixa e mostrou diminuicao significativa (p<0,05) em resposta a suplementacao com 200 g/d de fumarato de L-carnitina. A diminuicao dos triglicerideos hepaticos pode ser devido a um aumento na oxidacao de acidos graxos. Asuplementacao com L-carnitina aumentou significativamente (p<0,05) a concentracao de ureia no sangue, possivelmente atraves de um mecanismo de estimulacao do ciclo da ureia previamente descrito em outras especies. Conclusao: A suplementacao com L-carnitina diminuiu a concentracao hepatica de triglicerideos, possivelmente devido ao aumento da oxidacao de acidos graxos no figado. Palavras-chave: disturbios metabolicos; fatores lipotropicos; lipidose; L-carnitina; metabolismo lipidico; periparto; vacas leiteiras.
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The editors of Revista Colombiana de Ciencias Pecuarias (RCCP) welcome the submission of original manuscripts on experimental and clinical studies associated with the broad areas of animal sciences and veterinary medicine as they interface with biochemistry, molecular biology, physiology, pharmacology, toxicology, pathology, microbiology, parasitology, immunology and epidemiology. The scope of the journal includes studies of basic and applied research in animal management and production, feeding and nutrition, reproduction, breeding, genetics, animal welfare and behavior; as well as animal production focussed from biotechnology, soil science, agrostology, silvopastoral systems, livestock economics and the environment.
The criteria for acceptance of papers submitted for publication are originality, quality and clarity of the content. Each contribution must be based on original, unpublished research that has not been simultaneously submitted to other journals. All papers will be peer reviewed. All authors bear responsibility for ensuring the integrity and quality of their reported research. It is the author''s responsibility to secure permission to use figures or tables that have been published elsewhere.
Contributions may be classified as original research, review, rapid communication, clinical case studies or methodological articles, as well as news/commentaries or letters to the editor. Most review articles are invited by the editor. Authors interested in submitting a review article should contact the corresponding editor. Rapid publication of original manuscripts is a goal of the journal. Manuscripts must be written in English. Each manuscript is considered for publication with the understanding that it has not been simultaneously submitted to any other journal. Upon acceptance for publication, papers are subject to editorial review and revision.
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