Andrii I. Kysil, A. Biitseva, O. Bugera, T. Yegorova, Z. Voitenko
{"title":"2-(1,2,4-恶二唑-5-基)-2,3-二氢- 4h -铬-4-酮的合成","authors":"Andrii I. Kysil, A. Biitseva, O. Bugera, T. Yegorova, Z. Voitenko","doi":"10.17721/fujcv8i2p176-182","DOIUrl":null,"url":null,"abstract":"Simple and efficient synthesis of 2-(1,2,4-oxadiazol-5-yl)-2,3-dihydro-4H-chromen-4-ones is elaborated. The method relies on CDI-mediated cyclocondensation of substituted 4-oxochromane-2-carboxylic acids and amidoximes. The protocol allows the preparation of 2-oxadiazolylchromanones decorated with two pharmacophores (2,3-dihydro-4H-chromen-4-one and 1,2,4-oxadiazole) that are in high demand in drug discovery.","PeriodicalId":42056,"journal":{"name":"French-Ukrainian Journal of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.4000,"publicationDate":"2020-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis of 2-(1,2,4-oxadiazol-5-yl)-2,3-dihydro-4H-chromen-4-ones\",\"authors\":\"Andrii I. Kysil, A. Biitseva, O. Bugera, T. Yegorova, Z. Voitenko\",\"doi\":\"10.17721/fujcv8i2p176-182\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Simple and efficient synthesis of 2-(1,2,4-oxadiazol-5-yl)-2,3-dihydro-4H-chromen-4-ones is elaborated. The method relies on CDI-mediated cyclocondensation of substituted 4-oxochromane-2-carboxylic acids and amidoximes. The protocol allows the preparation of 2-oxadiazolylchromanones decorated with two pharmacophores (2,3-dihydro-4H-chromen-4-one and 1,2,4-oxadiazole) that are in high demand in drug discovery.\",\"PeriodicalId\":42056,\"journal\":{\"name\":\"French-Ukrainian Journal of Chemistry\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2020-12-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"French-Ukrainian Journal of Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17721/fujcv8i2p176-182\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"French-Ukrainian Journal of Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17721/fujcv8i2p176-182","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
摘要
介绍了2-(1,2,4-恶二唑-5-基)-2,3-二氢-4- h -铬-4-酮的简单高效合成方法。该方法依赖于cdi介导的取代4-氧-2-羧酸和偕胺肟的环缩合反应。该方案允许制备两种药物载体(2,3-二氢- 4h -铬-4- 1和1,2,4-恶二唑)修饰的2-恶二唑酮，这两种药物在药物发现中需求量很大。
Synthesis of 2-(1,2,4-oxadiazol-5-yl)-2,3-dihydro-4H-chromen-4-ones
Simple and efficient synthesis of 2-(1,2,4-oxadiazol-5-yl)-2,3-dihydro-4H-chromen-4-ones is elaborated. The method relies on CDI-mediated cyclocondensation of substituted 4-oxochromane-2-carboxylic acids and amidoximes. The protocol allows the preparation of 2-oxadiazolylchromanones decorated with two pharmacophores (2,3-dihydro-4H-chromen-4-one and 1,2,4-oxadiazole) that are in high demand in drug discovery.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
