{"title":"一项回顾性研究比较复发性LSIL细胞学与高级别细胞学作为高级别宫颈上皮内瘤变或更严重(CIN2+)预测指标的效率","authors":"R. Suleman, M. Botha","doi":"10.1080/20742835.2021.1962020","DOIUrl":null,"url":null,"abstract":"Background Cervical cancer (CC) is one of the most preventable cancers; however, it is the leading cause of cancer-related female deaths in South Africa. This study aimed to compare the efficiency of recurrent low-grade squamous intraepithelial lesion (LSIL) cytology as criteria to predict CIN2+ incidence, to a single initial high-grade squamous intraepithelial lesion (HSIL) cytology. Methods A retrospective cohort study comprising 344 women was conducted from January 2014 to December 2018 at the Colposcopy Clinic, Tygerberg Hospital. The women were categorised into two groups: (1) women with a recurrent LSIL cytology result, with recurrent cytology scheduled within 6–12 months; (2) women diagnosed with a single initial HSIL cytology result. The outcome was dichotomised into (1) normal or cervical intraepithelial neoplasia 1 (<CIN2) and (2) cervical intraepithelial neoplasia 2/3 or CC (CIN2+). Pearson’s chi-square test (X2) and Fisher’s exact test were used to assess any association between the patient-related factors considered and CIN2+ incidence. Results The sensitivity, specificity, PPV and NPV for referral HSIL cytology was 72.73% (95% CI 65.96–78.80), 79.10% (95% CI 71.24–85.64), 83.72% (95% CI 78.54–87.85) and 66.25% (95% CI 60.61–71.46), respectively. HIV status (p = 0.012) and ARV treatment (p = 0.015) were found to have statistically significant associations with CIN2+ incidence. Conclusions A single initial HSIL result is a more efficient predictor of CIN2+ incidence compared with a recurrent LSIL cytology result. The HIV-negative women were more accurately identified as CIN2+, compared with HIV-positive women. Women not on ARV treatment were more accurately identified as <CIN2+, compared with women on ARV treatment.","PeriodicalId":41638,"journal":{"name":"Southern African Journal of Gynaecological Oncology","volume":"13 1","pages":"18 - 25"},"PeriodicalIF":0.1000,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A retrospective study comparing the efficiency of recurrent LSIL cytology to high-grade cytology as predictors of high-grade cervical intraepithelial neoplasia or worse (CIN2+)\",\"authors\":\"R. Suleman, M. Botha\",\"doi\":\"10.1080/20742835.2021.1962020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background Cervical cancer (CC) is one of the most preventable cancers; however, it is the leading cause of cancer-related female deaths in South Africa. This study aimed to compare the efficiency of recurrent low-grade squamous intraepithelial lesion (LSIL) cytology as criteria to predict CIN2+ incidence, to a single initial high-grade squamous intraepithelial lesion (HSIL) cytology. Methods A retrospective cohort study comprising 344 women was conducted from January 2014 to December 2018 at the Colposcopy Clinic, Tygerberg Hospital. The women were categorised into two groups: (1) women with a recurrent LSIL cytology result, with recurrent cytology scheduled within 6–12 months; (2) women diagnosed with a single initial HSIL cytology result. The outcome was dichotomised into (1) normal or cervical intraepithelial neoplasia 1 (<CIN2) and (2) cervical intraepithelial neoplasia 2/3 or CC (CIN2+). Pearson’s chi-square test (X2) and Fisher’s exact test were used to assess any association between the patient-related factors considered and CIN2+ incidence. Results The sensitivity, specificity, PPV and NPV for referral HSIL cytology was 72.73% (95% CI 65.96–78.80), 79.10% (95% CI 71.24–85.64), 83.72% (95% CI 78.54–87.85) and 66.25% (95% CI 60.61–71.46), respectively. HIV status (p = 0.012) and ARV treatment (p = 0.015) were found to have statistically significant associations with CIN2+ incidence. Conclusions A single initial HSIL result is a more efficient predictor of CIN2+ incidence compared with a recurrent LSIL cytology result. The HIV-negative women were more accurately identified as CIN2+, compared with HIV-positive women. Women not on ARV treatment were more accurately identified as <CIN2+, compared with women on ARV treatment.\",\"PeriodicalId\":41638,\"journal\":{\"name\":\"Southern African Journal of Gynaecological Oncology\",\"volume\":\"13 1\",\"pages\":\"18 - 25\"},\"PeriodicalIF\":0.1000,\"publicationDate\":\"2021-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Southern African Journal of Gynaecological Oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/20742835.2021.1962020\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Southern African Journal of Gynaecological Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/20742835.2021.1962020","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
A retrospective study comparing the efficiency of recurrent LSIL cytology to high-grade cytology as predictors of high-grade cervical intraepithelial neoplasia or worse (CIN2+)
Background Cervical cancer (CC) is one of the most preventable cancers; however, it is the leading cause of cancer-related female deaths in South Africa. This study aimed to compare the efficiency of recurrent low-grade squamous intraepithelial lesion (LSIL) cytology as criteria to predict CIN2+ incidence, to a single initial high-grade squamous intraepithelial lesion (HSIL) cytology. Methods A retrospective cohort study comprising 344 women was conducted from January 2014 to December 2018 at the Colposcopy Clinic, Tygerberg Hospital. The women were categorised into two groups: (1) women with a recurrent LSIL cytology result, with recurrent cytology scheduled within 6–12 months; (2) women diagnosed with a single initial HSIL cytology result. The outcome was dichotomised into (1) normal or cervical intraepithelial neoplasia 1 (
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