妊娠期高血压疾病管理的最新进展

A. Gabra, M. Gabra
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摘要

妊娠期高血压疾病(HDP)很早就被发现,但对其发病机制的了解仍然有限。这些疾病可影响世界各地的许多孕妇,使她们、她们的家庭和她们的国家承受巨大的健康负担。所有关于HDP治疗的研究工作的主要目标是如何预防可能影响母亲和胎儿的HDP的高发病率并发症和死亡率。分娩是严重病例的主要治疗方法,但我们必须考虑到,在终止妊娠的情况下,除了可能发生子痫和产后高血压等并发症外,还可能出现早产的风险。研究人员认为,研究预防工作将导致全球范围内女性护理的重大改善,筛查肯定会让这些患者及时开始治疗,并防止进一步的序列。最近,许多指南支持并推荐阿司匹林81mg用于预防高危患者的子痫前期,并使用了关于服用时间和适应症的循证数据。在制定以证据为基础的指导方针以加强我们处理这些疾病的战略方面作出了巨大努力。回顾、汇总和比较这些指导方针将有助于我们完善我们的问题,这些问题可能需要进一步的研究来回答。试验证实,应用标准化策略治疗HDP可显著改善产妇和胎儿结局。在本文中,我们将回顾最近关于HDP治疗的更新和指南,并为您进一步阅读提供参考。
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Updates in Management of Hypertensive Disorders of Pregnancy
Hypertensive disorders of pregnancy (HDP) were discovered a long time ago but our knowledge about their etiopathogenesis are still limited. These disorders can affect many pregnant women all over the world putting them, their families and their countries under significant health burden. The main goal of all research efforts regarding treatment of HDP is how to prevent highly morbid complications and mortality of HDP that may affect both mother and fetus. Delivery is the main line of treatment for severe cases but we have to put in our mind risk of prematurity as a possible outcome in case of termination besides the possibility of incidence of complications like eclampsia and hypertensive emergency postnatally. Researchers believed that studies working on prevention would result in major improvement of overall women care worldwide, and screening will definitely allow prompt starting therapy for those patients and prevent further sequences. Recently many guidelines support and recommend Aspirin 81 mg for the prevention of preeclampsia in high-risk patients using evidence-based data about the time and indications of its intake. Great efforts have been contributed to developing evidence-based guidelines to enhance our strategies to deal with these disorders. Reviewing, pooling and comparing these guidelines would help us to refine our questions that may need to be answered by further studies. Trials confirmed that application of standardized strategies for treating HDP significantly improves both maternal and fetal outcomes. In this article, we are going to review recent updates and guidelines about the treatment of HDP and provide references for your further readings.
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