{"title":"发酵乳杆菌PL9988与肠上皮细胞的结合及抗炎活性","authors":"J. Paek, B. Kang, H. Yang, Y. Lee","doi":"10.37290/ijpp2641-7197.17:14-20","DOIUrl":null,"url":null,"abstract":"Lactobacillus fermentum PL9988 was isolated from an elderly person over 80 years of age living in a Korean longevity village. Results from a previous study showed various characteristics of L. fermentum PL9988 as a probiotic, including resistance to acid and bile acid, immune-enhancing activity, adhesiveness to the intestinal cell line Caco-2, inhibition of various intestinal pathogens, antioxidation activity, and susceptibility to antimicrobials. In this study, the binding activity of L. fermentum PL9988 to the intestine was confirmed in another human intestinal cell line, HT-29, and mouse intestinal cells. The anti-inflammatory activity of L. fermentum PL9988 was examined via both in vitro and in vivo experiments. Lactobacillus fermentum PL9988 increased the amount of IL-10 and decreased the amount of TNF-α in HT-29 cells treated with LPS. Similar results were observed in an in vivo experiment with BALB/c mice fed L. fermentum PL9988. Thus, results from the previous study and this study demonstrate the beneficial characteristics of L. fermentum PL9988 as a good probiotic with anti-inflammatory, antioxidative, and immune-enhancing activities in addition to improving intestinal health.","PeriodicalId":53704,"journal":{"name":"International Journal of Probiotics and Prebiotics","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Binding to Intestinal Epithelial Cells and Anti-Inflammatory Activity of Lactobacillus fermentum PL9988\",\"authors\":\"J. Paek, B. Kang, H. Yang, Y. Lee\",\"doi\":\"10.37290/ijpp2641-7197.17:14-20\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Lactobacillus fermentum PL9988 was isolated from an elderly person over 80 years of age living in a Korean longevity village. Results from a previous study showed various characteristics of L. fermentum PL9988 as a probiotic, including resistance to acid and bile acid, immune-enhancing activity, adhesiveness to the intestinal cell line Caco-2, inhibition of various intestinal pathogens, antioxidation activity, and susceptibility to antimicrobials. In this study, the binding activity of L. fermentum PL9988 to the intestine was confirmed in another human intestinal cell line, HT-29, and mouse intestinal cells. The anti-inflammatory activity of L. fermentum PL9988 was examined via both in vitro and in vivo experiments. Lactobacillus fermentum PL9988 increased the amount of IL-10 and decreased the amount of TNF-α in HT-29 cells treated with LPS. Similar results were observed in an in vivo experiment with BALB/c mice fed L. fermentum PL9988. Thus, results from the previous study and this study demonstrate the beneficial characteristics of L. fermentum PL9988 as a good probiotic with anti-inflammatory, antioxidative, and immune-enhancing activities in addition to improving intestinal health.\",\"PeriodicalId\":53704,\"journal\":{\"name\":\"International Journal of Probiotics and Prebiotics\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Probiotics and Prebiotics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37290/ijpp2641-7197.17:14-20\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Probiotics and Prebiotics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37290/ijpp2641-7197.17:14-20","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Binding to Intestinal Epithelial Cells and Anti-Inflammatory Activity of Lactobacillus fermentum PL9988
Lactobacillus fermentum PL9988 was isolated from an elderly person over 80 years of age living in a Korean longevity village. Results from a previous study showed various characteristics of L. fermentum PL9988 as a probiotic, including resistance to acid and bile acid, immune-enhancing activity, adhesiveness to the intestinal cell line Caco-2, inhibition of various intestinal pathogens, antioxidation activity, and susceptibility to antimicrobials. In this study, the binding activity of L. fermentum PL9988 to the intestine was confirmed in another human intestinal cell line, HT-29, and mouse intestinal cells. The anti-inflammatory activity of L. fermentum PL9988 was examined via both in vitro and in vivo experiments. Lactobacillus fermentum PL9988 increased the amount of IL-10 and decreased the amount of TNF-α in HT-29 cells treated with LPS. Similar results were observed in an in vivo experiment with BALB/c mice fed L. fermentum PL9988. Thus, results from the previous study and this study demonstrate the beneficial characteristics of L. fermentum PL9988 as a good probiotic with anti-inflammatory, antioxidative, and immune-enhancing activities in addition to improving intestinal health.
期刊介绍：
The International journal of Probiotics & Prebiotics publishes on online only in an open access format. This is a broad based international, interdisciplinary peer reviewed scientific journal for critical evaluation of research on prebiotics, probiotics and synbiotics. The major goal of this journal is to provide unbiased scientific data to students, researchers, healthcare providers, and the decision makers in the nutraceutical industry to help make informed choices about prebiotics, probiotics and synbiotics. To this end, the journal will publish original research articles and two types of review articles. First, we will publish a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, we will publish a critical evaluation of current human experimental data to help deliver products with medically proven use.
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