从远程医疗到自主人体健康和长期空间任务性能的范式转变

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-06-04 DOI:10.36001/ijphm.2019.v10i3.2627
A. Popov, W. Fink, A. Hess
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引用次数: 2

摘要

本文讨论了一种基于预测和健康管理[PHM]的方法来实现人类健康与绩效[HH&P]技术。具体目标是NASA综合技术路线图[2012年4月]技术区域06 [TA 06]中的NASA自主医疗决策和人类健康、生命支持和居住系统的综合生物医学信息学。提出的基于PHM的实现是将PHM(一门工程学科)与HH&P技术领域连接起来,通过专注于减少对抗质量和体积的努力来减轻太空旅行风险,并将风险降低到可接受的水平。NASA自主医疗决策技术基于无线手持设备,是远程医疗向HH&P自主模式转变的必然结果。综合生物医学信息技术基于机组人员电子健康记录(CEHR),配备了为机组人员而不是医疗保健专业人员使用而开发的预测诊断能力。本文从预测性诊断的角度进一步探讨了提出的基于phm的机组人员健康维护解决方案,为每个机组人员提供早期和可操作的实时警报,告知与健康相关的风险和即将发生的健康问题,否则这些问题可能无法被发现。本文还讨论了范式的假设及其创新方法,如计算生物标志物的实施。所建议的范式将在国际空间站(ISS)上进行验证,以确保该方法在固有预测能力和双容错方面的机组自主成为维持机组人员健康和性能的主要设计驱动因素。
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Paradigm Shift from Telemedicine to Autonomous Human Health and Performance for Long-Duration Space Missions
This paper discusses a Prognostics and Health Management [PHM]-based approach to implementing Human Health & Performance [HH&P] technologies. Targeted specifically are NASA Autonomous Medical Decision and Integrated Biomedical Informatics of Human Health, Life Support, and Habitation Systems in Technology Area 06 [TA 06] of NASA integrated technology roadmap [April 2012]. The proposed PHM-based implementation is to bridge PHM, an engineering discipline, to the HH&P technology domain to mitigate space travel risks by focusing on efforts to reduce countermeasure mass and volume, and drive down risks to an acceptable level. NASA Autonomous Medical Decision technology is based on wireless handheld devices and is a result of a necessary paradigm shift from telemedicine to HH&P autonomy. The Integrated Biomedical Informatics technology is based on Crew Electronic Health Records [CEHR], equipped with a predictive diagnostics capability developed for use by crew members rather than by healthcare professionals. This paper further explores the proposed PHM-based solutions for crew health maintenance in terms of predictive diagnostics to provide early and actionable real-time warnings to each crew member about health-related risks and impending health problems that otherwise might go undetected. The paper also discusses the paradigm’s hypothesis and its innovation methodology, as implemented with computed biomarkers. The suggested paradigm is to be validated on the International Space Station [ISS] to ensure that crew autonomy in terms of the inherent predictive capability and two-fault-tolerance of the methodology become the dominant design drivers in sustaining crew health and performance.
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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