Meigs syndrome caused by fibrothecoma of the ovary

Huge or enlarged solid ovarian tumor, elevated serum CA-125 levels, massive ascites, and even pleural effusions are common features of ovarian cancer which have the worst outcome of gynecological malignancy. Here, we report a 53-year-old woman with fibrothecoma-associated Meigs syndrome mimicking ovarian malignancy, whose symptoms resolved gradually, and subsequently, serum CA-125 level declined to normal range after surgical intervention. The pathological diagnosis revealed fibrothecoma of the ovary compatible with Meigs syndrome containing the triad of benign ovarian tumor, ascites, and pleural effusion. Therefore, Meigs syndrome should be considered one of the clinical differential diagnoses for a large ovarian tumor with ascites, pleural effusion, and elevated CA-125.