肠道微生物群、NAFLD和COVID-19:可能的相互作用

Obesities Pub Date : 2022-05-15 DOI:10.3390/obesities2020017
C. Finelli
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引用次数: 2

摘要

由SARS-CoV-2引起的新冠肺炎是世界各地的一个主要公共卫生问题。β冠状病毒家族包括通过ACE2受体进入细胞的严重急性呼吸系统综合征冠状病毒2型。中国武汉的第一例患者没有消化系统方面的症状。只有2.6%的人出现腹泻,只有2%的人患有慢性肝病。随着情况变得越来越复杂,越来越多的人报告胃部问题。该疾病的特点是腹泻、厌食、恶心、呕吐、腹部不适和胃肠道出血,其中腹泻是最常见的症状。关于胃肠道问题的起源,已经提出了几种理论。病毒通过ACE2诱导的细胞病变效应、免疫介导的炎性细胞因子风暴、肠肺轴功能和与药物相关的损伤,不仅在新冠肺炎病例中,而且在胃肠道疾病中也是如此。
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Gut Microbiota, NAFLD and COVID-19: A Possible Interaction
COVID-19, which is caused by SARS-CoV-2, is a major public health concern around the world. The beta coronavirus family includes SARS-CoV2, which enters cells via the ACE2 receptor. Patients in Wuhan, China, who suffered from the first sickness had no symptoms concerning the digestive system. Only 2.6% developed diarrhea, and only 2% had chronic liver illness. As the situation becomes more complicated, more people are reporting gastric issues. The disorder is characterized by diarrhea, anorexia, nausea, vomiting, abdominal discomfort and gastrointestinal bleeding, with diarrhea being the most common symptom. Several theories have been proposed for the genesis of gastrointestinal issues. Virus-induced cytopathic effects via ACE2, immune-mediated inflammatory cytokine storm, gut–lung axis function and drug-related damage are among them, not only in cases of COVID-19, but also in gastrointestinal illnesses.
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