One-pot Synthesis of Some New Betulinic Acid Derivatives with Cytotoxicity Against Human Pancreatic Cancer Cells

One-pot synthesis of new and biologically important betulinic acid derivatives has been designed and efficiently achieved in this work. The utilization of the carboxylic and hydroxyl moieties of betulinic acid has resulted in the development of a one-pot strategy towards the synthesis of some target compounds. One-pot synthesis of new betulinic acid derivatives 3-9 has been achieved in moderate to high yields by way of esterification of the carboxylic functionality with a variety of alkylating agents. These were fully characterized by spectroscopic techniques. The synthesized new derivatives of betulinic acid were screened for their cytotoxic effect against human pancreatic cancer cells.