了解生姜镇痛作用的分子机制

Corina Andrei, A. Zanfirescu, G. Nițulescu, S. Negreș
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摘要

慢性疼痛发病率高,对患者和社会影响深远,其治疗是临床实践中的一个真正挑战。生姜作为一种很有前景的镇痛药正在出现——对各种类型的疼痛都有效,并且患者耐受性良好。然而,我们才刚刚开始了解其复杂的作用机制。对其机制的充分了解将使我们能够充分利用这种草药的治疗潜力,并确定治疗慢性疼痛的更好策略。为了提供这些信息,我们检索了PubMed, SCOPUS和Web of Science,以研究生姜提取物或其成分的镇痛作用的体外研究或动物实验。数据分析是以叙述性审查的形式进行的。我们的研究表明,生姜提取物通过其多种有效成分,抑制伤害性信号的传递,同时激活疼痛的下行抑制通路。
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Understanding the Molecular Mechanisms Underlying the Analgesic Effect of Ginger
Chronic pain has a high prevalence and a profound impact on patients and society, and its treatment is a real challenge in clinical practice. Ginger is emerging as a promising analgesic—effective against various types of pain and well-tolerated by patients. However, we are just beginning to understand its complex mechanism of action. A good understanding of its mechanism would allow us to fully utilize the therapeutical potential of this herbal medicine as well as to identify a better strategy for treating chronic pain. To provide this information, we searched PubMed, SCOPUS, and Web of Science for in vitro studies or animal experiments investigating the analgesic effect of ginger extract or its components. The analysis of data was carried out in the form of a narrative review. Our research indicates that ginger extract, through its various active ingredients, suppresses the transmission of nociceptive signals while activating the descendent inhibitory pathways of pain.
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