地塞米松治疗急性呼吸窘迫综合征

Q4 Medicine Clinical Pulmonary Medicine Pub Date : 2020-09-01 DOI:10.1097/cpm.0000000000000378

W. Whalen, D. Zappetti

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摘要

简介：在中重度急性呼吸窘迫综合征（ARDS）患者中，定义为动脉氧分压/吸入氧分压（PaO2/FiO2）为200mmHg或更低，呼气末正压（PEEP）为10cm H2O或更大，FiO2>0.5，在ARDS发作后24小时内给予地塞米松可导致更多的无呼吸机天数，以及在不良事件没有差异的情况下降低全因死亡率。资料来源：Villar，J，Ferrando，C，Martínez，D等。地塞米松治疗急性呼吸窘迫综合征：一项多中心随机对照试验。《柳叶刀呼吸医学》2020；8:267–276。

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Dexamethasone in Acute Respiratory Distress Syndrome

Synopsis: In patients with moderate-to-severe acute respiratory distress syndrome (ARDS), defined as an arterial oxygen partial pressure/ fractional inspired oxygen (PaO2/FiO2) of 200 mmHg or less with a positive end-expiratory pressure (PEEP) of 10 cm H2O or greater and FiO2 > 0.5, administration of dexamethasone within 24 hours of ARDS onset led to more ventilator-free days, and a reduction of all-cause mortality with no difference in adverse events. Source: Villar, J, Ferrando, C, Martínez, D, et al. Dexamethasone treatment for the acute respiratory distress syndrome: a multicenter, randomised controlled trial. Lancet Respir Med. 2020;8:267–276.

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来源期刊

Clinical Pulmonary Medicine Medicine-Critical Care and Intensive Care Medicine

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期刊介绍： Clinical Pulmonary Medicine provides a forum for the discussion of important new knowledge in the field of pulmonary medicine that is of interest and relevance to the practitioner. This goal is achieved through mini-reviews on focused sub-specialty topics in areas covered within the journal. These areas include: Obstructive Airways Disease; Respiratory Infections; Interstitial, Inflammatory, and Occupational Diseases; Clinical Practice Management; Critical Care/Respiratory Care; Colleagues in Respiratory Medicine; and Topics in Respiratory Medicine.