紫曲霉毒素潜在的杀菌作用

IF 4.1 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Frontiers in Nanotechnology Pub Date : 2023-07-21 DOI:10.3389/fnano.2023.1186386
Ignacio Rivero Berti, M. Gantner, Santiago Rodriguez, G. A. Islan, W. Fávaro, A. Talevi, G. R. Castro, N. Durán
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引用次数: 0

摘要

紫花素是革兰氏阴性菌产生的一种色素,具有多种有益的生物活性。紫罗兰素最相关的活性包括干扰生物膜的生理活性、抑制细胞增殖、抗氧化和抗炎活性。此外,紫曲霉素对一些包膜和非包膜病毒的抗病毒活性也有报道。紫花素在实验和计算机上都表现出广泛的蛋白酶抑制作用。其他计算机研究表明,紫曲霉素与严重急性呼吸系统综合征冠状病毒2型刺突结合。经验物理化学研究表明,紫曲霉素(或偶尔其衍生物)可以口服治疗不同的疾病。此外,还综述了紫拉西素产品的不同替代品,以及该颜料的分子递送装置。
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Potential biocide roles of violacein
Violacein is a pigment produced by Gram-negative bacteria, which has shown several beneficial biological activities. The most relevant activities of violacein include the interference in the physiological activities of biological membranes, inhibition of cell proliferation, antioxidant, and anti-inflammatory activities. Moreover, the antiviral activities of violacein against some enveloped and non-enveloped viruses have also been reported. Violacein showed a wide spectrum of protease inhibition, both experimentally and in silico. Other in silico studies have suggested that violacein binds to the SARS-CoV-2 spike. Empirical physicochemical studies indicate that violacein (or, occasionally, its derivatives) may be administered orally to treat different disorders. In addition, different alternatives to product violacein, and molecular devices for delivery of this pigment are reviewed.
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来源期刊
Frontiers in Nanotechnology
Frontiers in Nanotechnology Engineering-Electrical and Electronic Engineering
CiteScore
7.10
自引率
0.00%
发文量
96
审稿时长
13 weeks
期刊最新文献
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