伊朗克尔曼教学医院选择性外科住院病人药物滥用的流行程度

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Journal of Reports in Pharmaceutical Sciences Pub Date : 2022-01-01 DOI:10.4103/jrptps.JRPTPS_35_22
G. Sepehri, M. Khaksari, Sara Vafadar, Hossein Satari
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引用次数: 0

摘要

背景:接受手术的患者在住院前滥用阿片类药物与疼痛管理、确定麻醉剂量和提供护理方面的挑战有关。本研究旨在评估接受择期大手术的住院患者的阿片类药物滥用/依赖性。材料和方法:共有1000名择期大手术患者接受了人口统计学特征、围手术期和术后疼痛管理、阿片类药物滥用的类型和途径以及其他滥用药物的当前使用情况评估。结果:34%的外科住院患者存在药物滥用。药物滥用的平均持续时间为4.3 ± 1.9年。阿片类药物是最常被滥用的物质(67.9%),其次是纳斯瓦尔(16.4%)和大麻(8.5%)。吸入途径(60%)是阿片类物质最常见的使用途径,其次是注射途径(29.4%)和口服途径(10.6%)。女性阿片类滥用的流行率(54.6%)显著高于男性(45.4%),(P=0.032,奇数比=1.18,95%CI=1.03-1.42)。低教育水平与较高的药物滥用率相关(P=0.042,奇数比1.39,95%CI=1.14-1.64),但性别、教育水平和药物滥用类型之间没有显著相关性。总体而言,阿片类药物滥用和依赖与缓解术后疼痛的阿片类止痛药需求增加至少30%有关。阿片类药物滥用患者未记录到阿片类物质戒断症状。结论:结果显示,超过三分之一的外科住院患者(34%)滥用药物,女性的药物滥用率更高,这是一个意外的发现。阿片类药物滥用与教育水平显著相关。阿片类药物依赖患者在术后接受更高剂量的阿片类。由于阿片类药物滥用会影响术前和术后的手术和护理专业人员,尤其是护士,在照顾这些人时需要持续的医学教育和专业支持。
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The prevalence of substance abuse among elective surgical inpatients in teaching hospitals in Kerman, Iran
Background: Opioid abuse prior to hospitalization in patients undergoing surgical procedures is associated with challenges in pain management, determining anesthetic dose, and providing nursing care. This study aimed to evaluate opioid abuse/dependence in hospitalized patients undergoing major elective surgery. Materials and Methods: A total of 1000 patients who were candidates for major elective surgery were assessed for demographic characteristics, perioperative and postoperative pain management, type and route of opioid abuse, and the current use of other abused substances. Results: Substance abuse was observed in 34% of surgical inpatients. The mean duration of substance abuse was 4.3 ± 1.9 years. Opioids were the most frequently abused substances (67.9%), followed by naswar (16.4%) and marijuana (8.5%). The inhalation route (60%) was the most common route for opioid use, followed by injection (29.4%) and oral route (10.6%). The prevalence of opioid abuse in females (54.6%) was significantly higher than males (45.4%), (P = 0.032, odd ratio =1.18, 95% CI = 1.03 -1.42). Low education level was associated with a higher rate of substance abuse (P = 0.042, Odd ratio=1.39, 95% CI = 1.14 -1.64), but there was no significant correlation between sex, education level, and substance abuse type. Overall, opioid abuse and dependence were associated with at least a 30% increase in the need for opioid analgesics to relieve postoperative pain. No opioid withdrawal signs were recorded in opioid-abusing patients. Conclusion: The results showed substance/drug abuse in more than one-third of surgical inpatients (34%) and a higher rate of drug abuse in women, which was an unexpected finding. Opioid abuse was significantly associated with education level. Opioid-dependent patients received higher doses of opioids during postoperative periods. Since opioid abuse can affect both preoperative and postoperative surgical and nursing health professionals, especially nurses, need continued medical education and professional support in caring for these individuals.
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来源期刊
Journal of Reports in Pharmaceutical Sciences
Journal of Reports in Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.40
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期刊介绍: The Journal of Reports in Pharmaceutical Sciences(JRPS) is a biannually peer-reviewed multi-disciplinary pharmaceutical publication to serve as a means for scientific information exchange in the international pharmaceutical forum. It accepts novel findings that contribute to advancement of scientific knowledge in pharmaceutical fields that not published or under consideration for publication anywhere else for publication in JRPS as original research article. all aspects of pharmaceutical sciences consist of medicinal chemistry, molecular modeling, drug design, pharmaceutics, biopharmacy, pharmaceutical nanotechnology, pharmacognosy, natural products, pharmaceutical biotechnology, pharmacology, toxicology and clinical pharmacy.
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