Therapeutic interfaces of honey in diabetic wound pathology

Diabetic wound healing is one of the most universally acclaimed arduous medical challenges. In diabetics, once an ulcer gets evolved, there remains a heightened threat of wound progression and persistence. This review denatures the entangled helices of system pathology of diabetic wounds by providing explicit information regarding mechanobiological, oxidative stress related, growth factor associated episodes and also explores two unique pathophysiological events appellated ‘NETosis’ and ‘Metabolic Memory’. In this juncture, we further try to subsume the concept of contemporary alleviation via introducing age old natural medicine honey that may augment the inflows of regenerative windows in mammalian systems to restore homeostatic dimensions of healing in the wound bed.