被遗忘的一些无毒树状大分子结构用于靶向药物递送

IF 1.8 3区 化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR Main Group Metal Chemistry Pub Date : 2021-01-01 DOI:10.1515/mgmc-2021-0004
Y. Ali, Zainab Bibi, Quanita Kiran
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引用次数: 4

摘要

摘要近年来,卟啉基树状大分子因其在纳米器件和光动力治疗中的应用而受到极大的关注。基于纳米材料或树枝状聚合物的新技术有可能克服传统药物递送带来的问题,如药物的毒性、溶解性差和释放模式差。这些高度支化的纳米树枝状聚合物的化学和物理性质取决于它们的结构。在化学网络理论中,各种拓扑指数被用来预测分子(树枝状聚合物)的化学性质。在许多有用的拓扑描述符中,被遗忘的condex相对较少被探索,但在材料工程、制药和化学工业中非常有用。在本文中,我们考虑了一些特殊的树枝状聚合物,如聚(丙基)醚亚胺、卟啉和锌卟啉,以及纳米星,如D1[k]和D2[k],并计算了这些重要结构的遗忘指数。
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Forgotten coindex of some non-toxic dendrimers structure used in targeted drug delivery
Abstract In recent past, porphyrin-based dendrimers have gained great attraction due to their usefulness in nano devices and photo-dynamic therapy. New technologies based upon nano-materials or dendrimers have potential to overcome the problems due to conventional drug delivery, like toxicity, poor solubility and poor release pattern of drugs. The chemical and physical properties of these highly branched nanometer sized dendrimers depend on their structure. In chemical network theory, various topological indices are used to predict chemical properties of molecules(dendrimers). Among many useful topological descriptors forgotten coindex is relatively less explored but is found very useful in material engineering, pharmaceutical and chemical industries. In this article, we consider some special dendrimers, like poly(propyl) ether imine, porphyrin, and zinc-porphyrin, and nanostars like D1[k] and D2[k] and compute forgotten coindex for these important structures.
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来源期刊
Main Group Metal Chemistry
Main Group Metal Chemistry CHEMISTRY, INORGANIC & NUCLEAR-CHEMISTRY, ORGANIC
CiteScore
4.10
自引率
27.80%
发文量
21
审稿时长
4 weeks
期刊介绍: This journal is committed to the publication of short communications, original research, and review articles within the field of main group metal and semi-metal chemistry, Main Group Metal Chemistry is an open-access, peer-reviewed journal that publishes in ongoing way. Papers addressing the theoretical, spectroscopic, mechanistic and synthetic aspects of inorganic, coordination and organometallic main group metal and semi-metal compounds, including zinc, cadmium and mercury are welcome. The journal also publishes studies relating to environmental aspects of these metals, their toxicology, release pathways and fate. Articles on the applications of main group metal chemistry, including in the fields of polymer chemistry, agriculture, electronics and catalysis, are also accepted.
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