{"title":"基于ICP-MS的金属组学方法论：单颗粒分析、单细胞分析和空间金属组学","authors":"Mingli Chen, Meng Wang","doi":"10.46770/as.2022.108","DOIUrl":null,"url":null,"abstract":": As an emerging interdisciplinary science, metallomics aims to integrate research fields related to metals and metalloids in biological systems from a systematic perspective. Inductively coupled plasma mass spectrometry (ICP-MS) is considered one of the most versatile tools for metallomics research. This review presents a brief overview of ICP-MS and describes recent advances in ICP-MS instrumentation. Then, ICP-MS-based methods and applications are discussed, focusing on single particle analysis, single cell analysis, and spatial metallomics. With the rapid developments in instrumentation and methodology, ICP-MS-based methodologies will evolve further and play a dominant role in metallomics research.","PeriodicalId":8642,"journal":{"name":"Atomic Spectroscopy","volume":" ","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"9","resultStr":"{\"title\":\"ICP-MS-Based Methodology In Metallomics: Towards Single Particle Analysis, Single Cell Analysis, And Spatial Metallomics\",\"authors\":\"Mingli Chen, Meng Wang\",\"doi\":\"10.46770/as.2022.108\",\"DOIUrl\":null,\"url\":null,\"abstract\":\": As an emerging interdisciplinary science, metallomics aims to integrate research fields related to metals and metalloids in biological systems from a systematic perspective. Inductively coupled plasma mass spectrometry (ICP-MS) is considered one of the most versatile tools for metallomics research. This review presents a brief overview of ICP-MS and describes recent advances in ICP-MS instrumentation. Then, ICP-MS-based methods and applications are discussed, focusing on single particle analysis, single cell analysis, and spatial metallomics. With the rapid developments in instrumentation and methodology, ICP-MS-based methodologies will evolve further and play a dominant role in metallomics research.\",\"PeriodicalId\":8642,\"journal\":{\"name\":\"Atomic Spectroscopy\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2022-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Atomic Spectroscopy\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.46770/as.2022.108\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"SPECTROSCOPY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Atomic Spectroscopy","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.46770/as.2022.108","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SPECTROSCOPY","Score":null,"Total":0}
ICP-MS-Based Methodology In Metallomics: Towards Single Particle Analysis, Single Cell Analysis, And Spatial Metallomics
: As an emerging interdisciplinary science, metallomics aims to integrate research fields related to metals and metalloids in biological systems from a systematic perspective. Inductively coupled plasma mass spectrometry (ICP-MS) is considered one of the most versatile tools for metallomics research. This review presents a brief overview of ICP-MS and describes recent advances in ICP-MS instrumentation. Then, ICP-MS-based methods and applications are discussed, focusing on single particle analysis, single cell analysis, and spatial metallomics. With the rapid developments in instrumentation and methodology, ICP-MS-based methodologies will evolve further and play a dominant role in metallomics research.
期刊介绍：
The ATOMIC SPECTROSCOPY is a peer-reviewed international journal started in 1962 by Dr. Walter Slavin and now is published by Atomic Spectroscopy Press Limited (ASPL). It is intended for the rapid publication of both original articles and review articles in the fields of AAS, AFS, ICP-OES, ICP-MS, GD-MS, TIMS, SIMS, AMS, LIBS, XRF and related techniques. Manuscripts dealing with (i) instrumentation & fundamentals, (ii) methodology development & applications, and (iii) standard reference materials (SRMs) development can be submitted for publication.
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