Expression and significance of ring finger protein 43 in breast cancer

Objective To investigate the expression and significance of ring finger protein 43 (RNF43) in human breast cancer tissue. Methods Real-time quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR) and Western blotting were used to detect the mRNA and protein expression levels of RNF43 in breast cancertissues (60 cases) and normaladjacent tissues (60 cases). Results The expression of RNF43 mRNA and protein in breast cancer tissues (1.216±0.112, 0.439±0.056) was significantly higher than that in adjacent normal breast tissues (0.253±0.018, 0.107±0.015) (P 2 cm group: 1.262±0.014, 0.450±0.030), pathological type (invasive ductal carcinoma group: 1.243±0.079, 0.448±0.011; invasive lobular carcinoma group: 1.108±0.044, 0.403±0.013), human epidermalgrowth factor receptor-2 (Her-2) expression (positive group: 1.178±0.009, 0.422±0.017; negative group: 1.230±0.011, 0.445±0.010) and menstrual status (premenopausal: 1.231±0.049, 0.440±0.008; postmenopausal: 1.167±0.056, 0.436±0.011) (P>0.05). Conclusion The abnormal expression of RNF43 mRNA and protein may be Associated with the oncogenesis, progress, invasion and metastasis, and may be a important prognostic predictor of breast cancer. Key words: Ring finger protein 43; Breast cancer; Metastasis