当前对糖尿病性血脂异常的认识综述

IF 1.8 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES Journal of the Indian Institute of Science Pub Date : 2022-12-13 DOI:10.1007/s41745-022-00346-5
Arvind Gupta, Rajeev Gupta
{"title":"当前对糖尿病性血脂异常的认识综述","authors":"Arvind Gupta,&nbsp;Rajeev Gupta","doi":"10.1007/s41745-022-00346-5","DOIUrl":null,"url":null,"abstract":"<div><p>Diabetes is a chronic disease associated with a variety of metabolic abnormalities. Principal cause of disability and deaths in diabetes are coronary, peripheral, and cerebral vascular diseases mainly due to lipid abnormalities. Diabetic dyslipidemia is characterized by elevated small-dense low-density lipoprotein (LDL) cholesterol and triglycerides (TG) and low high-density lipoprotein (HDL) cholesterol. Elevated LDL cholesterol has been proven as causative for cardiovascular disease. Treatment thresholds for this variable have been advocated in multiple clinical practice recommendations and intensity of LDL lowering is dependent on associated risk factors. Statins are mainstay for treatment although combination therapies with ezetimibe and PCSK9 inhibitors are needed in very high-risk individuals. Recent research has confirmed role of raised TG as a cardiovascular risk factor. However, limited options are currently available as drug therapy. Low HDL cholesterol appears to be less of a contributor to cardiovascular risk than previously considered a risk marker. Primary cardiovascular disease prevention strategies in diabetes should focus on risk assessment, aggressive lifestyle interventions and treatment with statins, etc. In the present review we have focused on role of lipids in pathophysiology of diabetes associated cardiovascular disease and focus on evidence guided management.</p></div>","PeriodicalId":675,"journal":{"name":"Journal of the Indian Institute of Science","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41745-022-00346-5.pdf","citationCount":"0","resultStr":"{\"title\":\"Current Understanding of Diabetic Dyslipidemia: A Review\",\"authors\":\"Arvind Gupta,&nbsp;Rajeev Gupta\",\"doi\":\"10.1007/s41745-022-00346-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Diabetes is a chronic disease associated with a variety of metabolic abnormalities. Principal cause of disability and deaths in diabetes are coronary, peripheral, and cerebral vascular diseases mainly due to lipid abnormalities. Diabetic dyslipidemia is characterized by elevated small-dense low-density lipoprotein (LDL) cholesterol and triglycerides (TG) and low high-density lipoprotein (HDL) cholesterol. Elevated LDL cholesterol has been proven as causative for cardiovascular disease. Treatment thresholds for this variable have been advocated in multiple clinical practice recommendations and intensity of LDL lowering is dependent on associated risk factors. Statins are mainstay for treatment although combination therapies with ezetimibe and PCSK9 inhibitors are needed in very high-risk individuals. Recent research has confirmed role of raised TG as a cardiovascular risk factor. However, limited options are currently available as drug therapy. Low HDL cholesterol appears to be less of a contributor to cardiovascular risk than previously considered a risk marker. Primary cardiovascular disease prevention strategies in diabetes should focus on risk assessment, aggressive lifestyle interventions and treatment with statins, etc. In the present review we have focused on role of lipids in pathophysiology of diabetes associated cardiovascular disease and focus on evidence guided management.</p></div>\",\"PeriodicalId\":675,\"journal\":{\"name\":\"Journal of the Indian Institute of Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2022-12-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s41745-022-00346-5.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Indian Institute of Science\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s41745-022-00346-5\",\"RegionNum\":4,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Indian Institute of Science","FirstCategoryId":"103","ListUrlMain":"https://link.springer.com/article/10.1007/s41745-022-00346-5","RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

糖尿病是一种与多种代谢异常相关的慢性疾病。糖尿病致残和死亡的主要原因是主要由脂质异常引起的冠状动脉、外周血管和脑血管疾病。糖尿病性血脂异常的特征是小密度低密度脂蛋白(LDL)胆固醇、甘油三酯(TG)和低密度脂蛋白(HDL)胆固醇升高。低密度脂蛋白胆固醇升高已被证明是心血管疾病的诱因。在多个临床实践建议中,已提倡针对该变量的治疗阈值,并且LDL降低的强度取决于相关的危险因素。他汀类药物是主要的治疗方法,尽管在高危人群中需要与依折替米贝和PCSK9抑制剂联合治疗。最近的研究证实了TG升高作为心血管危险因素的作用。然而,目前可供选择的药物治疗方法有限。低高密度脂蛋白胆固醇对心血管风险的影响似乎比以前认为的风险标志要小。糖尿病的初级心血管疾病预防策略应侧重于风险评估、积极的生活方式干预和他汀类药物治疗等。在目前的回顾中,我们主要关注脂质在糖尿病相关心血管疾病的病理生理中的作用,并重点关注循证指导的管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Current Understanding of Diabetic Dyslipidemia: A Review

Diabetes is a chronic disease associated with a variety of metabolic abnormalities. Principal cause of disability and deaths in diabetes are coronary, peripheral, and cerebral vascular diseases mainly due to lipid abnormalities. Diabetic dyslipidemia is characterized by elevated small-dense low-density lipoprotein (LDL) cholesterol and triglycerides (TG) and low high-density lipoprotein (HDL) cholesterol. Elevated LDL cholesterol has been proven as causative for cardiovascular disease. Treatment thresholds for this variable have been advocated in multiple clinical practice recommendations and intensity of LDL lowering is dependent on associated risk factors. Statins are mainstay for treatment although combination therapies with ezetimibe and PCSK9 inhibitors are needed in very high-risk individuals. Recent research has confirmed role of raised TG as a cardiovascular risk factor. However, limited options are currently available as drug therapy. Low HDL cholesterol appears to be less of a contributor to cardiovascular risk than previously considered a risk marker. Primary cardiovascular disease prevention strategies in diabetes should focus on risk assessment, aggressive lifestyle interventions and treatment with statins, etc. In the present review we have focused on role of lipids in pathophysiology of diabetes associated cardiovascular disease and focus on evidence guided management.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of the Indian Institute of Science
Journal of the Indian Institute of Science MULTIDISCIPLINARY SCIENCES-
CiteScore
4.30
自引率
0.00%
发文量
75
期刊介绍: Started in 1914 as the second scientific journal to be published from India, the Journal of the Indian Institute of Science became a multidisciplinary reviews journal covering all disciplines of science, engineering and technology in 2007. Since then each issue is devoted to a specific topic of contemporary research interest and guest-edited by eminent researchers. Authors selected by the Guest Editor(s) and/or the Editorial Board are invited to submit their review articles; each issue is expected to serve as a state-of-the-art review of a topic from multiple viewpoints.
期刊最新文献
Review on Management of Heavy Metal Contaminated Sediment: Remediation Strategies and Reuse Potential Paradigm Shifts in Building Construction Priorities in the Last Decade Examining Bengaluru’s Potable Water Quality and the Usage and Consequences of Reverse Osmosis Technology in Treating the City’s Drinking Water Review of CFD Based Simulations to Study the Hemodynamics of Cerebral Aneurysms Correction: An Indian Tribute to William Morton Wheeler
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1