右美托咪定氯胺酮与丙泊酚在锁骨上臂丛神经阻滞下上肢手术中的先发制人麻醉:一项随机对照试验

IF 0.2 Q4 ANESTHESIOLOGY Indian Anaesthetists Forum Pub Date : 2022-07-01 DOI:10.4103/TheIAForum.TheIAForum_42_22
Mehul V. Makwana, Bhumika Pathak, Niral Panchal, M. Chaudhari, A. Phatak
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引用次数: 1

摘要

背景和目的:局部麻醉前和麻醉中镇痛镇静具有镇痛、抗焦虑和健忘症的作用。本研究比较了氯胺酮-右美托咪定(KD)与氯胺酮-异丙酚(KP)在锁骨上臂丛阻滞下的镇静、针刺疼痛、血流动力学和副作用。材料与方法:经伦理委员会批准、CTRI注册和患者同意后,纳入75例符合纳入和排除标准的患者。患者分为两组。KP组先给氯胺酮0.5 mg/kg、异丙酚1 mg/kg负荷10 min,再给氯胺酮0.3 mg/kg/h、异丙酚10 μg/kg/min维持剂量。KD组给予氯胺酮0.5 mg/kg、右美托咪定0.5 μg/kg负荷剂量,持续10 min,随后给予氯胺酮0.3 mg/kg/h、右美托咪定0.3 μg/kg/h维持剂量。监测患者的镇静、阻滞时针刺疼痛、研究药物的副作用、血流动力学和呼吸参数。采用独立样本t检验比较连续结局,采用描述性统计描述研究参与者的基线概况,采用卡方检验比较分类结局。P < 0.05为差异有统计学意义。结果:KD组和KP组针刺痛发生率分别为5.7%和42.9%。KD组28.6%和KP组5.7%的患者出现恶心。结论:与KP组相比,KD组具有足够的镇静作用,且锁骨上阻滞时针刺疼痛减轻。KD组恶心发生率高于KP组。
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Preemptive analgosedation with ketamine-dexmedetomidine versus ketamine-propofol in upper limb surgeries under supraclavicular brachial plexus block: A randomized controlled trial
Background and Aims: Analgosedation before and during regional anesthesia provides analgesia, anxiolysis, and amnesia. This study has been conducted to compare ketamine-dexmedetomidine (KD) versus ketamine-propofol (KP) for sedation, pain on needle prick while giving block, hemodynamics, and their side effects under supraclavicular brachial plexus block. Materials and Methods: After obtaining ethics committee approval, CTRI registration and patient consent, 75 patients were recruited who satisfy inclusion and exclusion criteria. Patients were divided into two groups. Group KP received a loading dose of ketamine 0.5 mg/kg, propofol 1 mg/kg over 10 min, followed by a maintenance dose of ketamine 0.3 mg/kg/h and propofol 10 μg/kg/min. Group KD received loading dose of ketamine 0.5 mg/kg, dexmedetomidine 0.5 μg/kg over 10 min, followed by maintenance dose of ketamine 0.3 mg/kg/h and dexmedetomidine 0.3 μg/kg/h. Patients were monitored for sedation, pain on needle prick while performing block, side effects of study drugs, hemodynamic and respiratory parameters. An independent sample t-test was used to compare continuous outcomes, descriptive statistics were used to depict the baseline profile of the study participants, Chi-square test was used to compare the categorical outcomes. A value of P < 0.05 was considered statistically significant. Results: Pain on needle prick was experienced in 5.7% and 42.9% in Group KD and Group KP, respectively. In Group KD, 28.6% and Group KP 5.7% of patients experienced nausea. Conclusion: In this study, group KD has adequate sedation as compared to group KP with less pain on needle prick while performing supraclavicular block. Group KD has higher incidence of nausea than gruop KP.
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来源期刊
Indian Anaesthetists Forum
Indian Anaesthetists Forum ANESTHESIOLOGY-
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审稿时长
6 weeks
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