伴有和不伴有多囊卵巢综合征的不孕妇女卵巢储备标志物与体重指数的关系:一项回顾性病例对照研究

IF 1.1 Q4 OBSTETRICS & GYNECOLOGY Reproductive medicine (Basel, Switzerland) Pub Date : 2023-08-17 DOI:10.3390/reprodmed4030018
L. Casadei, I. Nacci, V. Vicomandi, R. Sorge, C. Ticconi
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引用次数: 0

摘要

本研究对94名多囊卵巢综合征(PCOS)女性和176名非PCOS女性进行了研究,探讨了体重指数(BMI)对不育患者血清抗勒氏激素(AMH)、促卵泡激素(FSH)、促黄体生成素(LH)和17ß-雌二醇(E2)水平的影响。根据年龄(<35岁或≥35岁)和BMI (<25 kg/m2或≥25 kg/m2)将患者分为4个亚组。在大多数感兴趣的参数方面,观察到pcos影响妇女和对照组妇女之间的显著差异。在pcos患者和对照组中,年龄与AMH呈负相关。在对照组中,年龄与FSH和LH直接相关。在受多囊卵巢综合征影响的女性中,除了FSH外,BMI与血清AMH、E2和LH水平没有相关性。在对照组女性中,BMI和卵巢储备指标之间没有相关性。无论是否存在多囊卵巢综合征,BMI在四个亚组中均与AMH无关。仅在BMI < 25/FSH和BMI≥25/LH之间发现年龄≥35岁的pcos患者呈负相关。研究了96例年龄≤37岁的对照女性BMI与排卵障碍(OD)之间的可能关系。在有OD的女性中,BMI值明显高于无OD的患者,FSH和E2水平明显低于无OD的患者。综上所述,我们的数据表明,BMI与卵巢储备的激素参数无关,无论是否存在PCOS, BMI可能影响排卵障碍,而不是导致卵巢储备下降。
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Relationship between Ovarian Reserve Markers and Body Mass Index in Infertile Women with and without Polycystic Ovary Syndrome: A Retrospective Case–Control Study
This study, carried out on 94 women with polycystic ovary syndrome (PCOS) and 176 controls without it, investigated the influence of body mass index (BMI) on serum levels of antimüllerian hormone (AMH), follicle stimulating hormone (FSH), luteinizing hormone (LH), and 17ß-estradiol (E2) in infertile patients. Patients were assigned to four subgroups according to age (<35 or ≥35 years) and BMI (<25 kg/m2 or ≥25 kg/m2). Significant differences between PCOS-affected and control women were observed with respect to most of the parameters of interest. In both PCOS-affected and control women, age was inversely correlated with AMH. In the control patients, age was directly correlated with FSH and LH. In women affected by PCOS, no correlation was found between BMI and serum levels of AMH, E2, and LH, except FSH. No correlation was found between BMI and markers of ovarian reserve in control women. BMI was not correlated with AMH in any of the four subgroups considered regardless of the presence of PCOS. An inverse correlation was found only in PCOS-affected women aged ≥35 years between a BMI < 25/FSH and a BMI ≥ 25/LH. The possible association between BMI and ovulation disorder (OD) was investigated in 96 control women aged ≤37 years. In women with OD, the BMI values were significantly higher and FSH and E2 levels were lower than those of patients without OD. Taken together, our data suggest that BMI is not related to hormonal parameters of ovarian reserve, irrespective of the presence of PCOS, and could influence ovulation disorder rather than cause a decrease in ovarian reserve.
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