毛上皮瘤内发生基底细胞癌:免疫组织化学研究

V. Bartoš, Martin Biopsy
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摘要

摘要背景:皮肤毛上皮瘤(TE)和基底细胞癌(BCC)是不同的肿瘤实体,但它们具有密切的组织遗传学和表型关系。目的:描述一例在TE内发生的BCC的独特病例,重点分析不同肿瘤类型和每种肿瘤类型的典型免疫表型。材料和方法:一位71岁的男性,在腰椎区域出现皮下实体瘤。采用免疫组织化学方法对切除的肿瘤标本进行研究。结果:组织学显示典型TE和结节性BCC共存。两种肿瘤均为BerEP4强阳性,EMA阴性。BCC的新生上皮显示Bcl-2的弥漫性染色,而TE几乎只在肿瘤岛的外周细胞中表达Bcl-2。在基底细胞癌中,肿瘤结节显示CD10的局灶性染色,而瘤周间质则没有。相反,TE在肿瘤岛周围的基质细胞中显示CD10的局灶性免疫反应性,完全阴性。TE含有肿瘤内CK20标记的Merkel细胞,但在BCC中未检测到。在两种肿瘤中都发现了CD34的基质免疫再活性。BCC的增殖活性(Ki-67)略高于TE。结论:尽管在同一皮肤病变中同时存在TE和BCC是一种独特的发现,但在活检实践中有时也会遇到这种情况。病理学家应通过精确的切片取样对整个TE病变进行仔细的组织学检查,以揭示这种可能的相关性。
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Basal Cell Carcinoma Arising within a Trichoepithelioma: An Immunohistochemical Study
Abstract Background: Trichoepithelioma (TE) and basal cell carcinoma (BCC) of skin represent distinct tumor entities but they have a close histogenetic and phenotypic relationship. Objective: A unique case of a BCC arising within a TE is described with an emphasis on the analysis of different and for each tumor type typical immunophenotype. Material and Methods: A 71-year-old man presented with a subcutaneous solid tumor in the lumbar region. The resected tumor specimen was studied by immunohistochemistry. Results: Histology revealed a coexistence of classic TE and nodular BCC. Both tumors were strongly positive for BerEP4 and negative for EMA. Neoplastic epithelium of the BCC showed a diffuse staining for Bcl-2, while the TE expressed Bcl-2 almost exclusively in the peripheral cells of tumor islands. In the BCC, neoplastic nodules exhibited a focal staining for CD10, while the peritumorous stroma did not. In contrast, the TE showed a focal immunoreactivity for CD10 in the stromal cells around the neoplastic islands which were completely negative. The TE contained intratumorous CK20-labeled Merkel cells but they were not detected in the BCC. A stromal immunore-activity for CD34 was found in both tumors. Proliferative activity (Ki-67) was slightly higher in the BCC than in the TE. Conclusion: Although a concomitant presence of TE and BCC in the same skin lesion is a unique finding, it may be sometimes encountered in a biopsy practice. Pathologists should provide a careful histologic examination of the whole TE lesion with precise section sampling to unveil such possible association.
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来源期刊
自引率
0.00%
发文量
11
审稿时长
14 weeks
期刊介绍: Acta Medica Martiniana is a medical scientific journal, first published in print form in December 2001. It is a continuation of the journal / almanac Folia Medica Martiniana (1971 - 1996). The journal‘s owner is the Jessenius Faculty of Medicine, Comenius University, Slovakia. Dissemination of research results and scientific knowledge from all areas of medicine and nursing. Stimulation, facilitation and supporting of publication activity for the young medical research and clinical generation. The contributions of young novice authors (PhD students and post-doctorials) are particularly welcome. Acta Medica Martiniana is an open-access journal, with a periodicity of publishing three times per year (Apr/Aug/Dec). It covers a wide range of basic medical disciplines, such as anatomy, histology, biochemistry, human physiology, pharmacology, etc., as well as all clinical areas incl. preventive medicine, public health and nursing. Interdisciplinary and multidisciplinary manuscripts, including papers from all areas of biomedical research, are welcome.
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