Effect of shilajit on the levels of pro-inflammatory and anti inflammatory cytokines in ulcerative colitis induced by acetic acid in male rats

Background: The levels of IL-13, IL-4, IL-1B, TNF-α and IL-10 alter in the colon of people with ulcerative colitis. previous studies, it was found that shilajit (asphaltum) was effective in the improvement of ulcerative colitis.we guessed that the shilajit has been able to improve the ulcerative colitis by affecting the amount of cytokines. Objective: The aim of the present study was to investigate the effects of shilajit on IL-13, IL-4, IL-1B, TNF-α and IL-10 in ulcerative colitis. Methods: In this experimental study, 49 white 7 groups colitis, Gavage shilajit, colitis Results: The Gavage shilajit group increased IL-10, IL-4and IL-1β, TNF-α compared to Gavage vehicle group. Shilajit able to close the levels of IL-4, IL-13, IL-10, TNF-α to normal values the sham group. Conclusion: Considering that the of intestinal the of rat the shilajit lower than it can be shown that shilajit has been able to more reduce more suitable change in