局部利多卡因中毒致癫痫持续状态1例:附病例报告及文献复习

IF 0.3 Q4 PEDIATRICS Journal of Pediatrics Review Pub Date : 2022-03-06 DOI:10.32598/jpr.10.1.979.1
Arman Hakemi, Behrang Rezvani Kakhki, S. Sadrzadeh, S. Mousavi, Elnaz Vafadar Moradi
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引用次数: 0

摘要

简介:盐酸利多卡因是乙酰胺衍生物,于1943年由Nils Löfgrene首次引入。它是一种广泛使用的局麻药,在日常实践中为伤口修复病人做准备。已报道全身和外用利多卡因有神经毒性。病例介绍:一名8岁女童,在接受利多卡因和氯胺酮治疗后出现单纯的撕裂伤,并发癫痫持续状态。患者无癫痫史,无过敏反应,身心发育正常。给予200毫克利多卡因不加肾上腺素,并行伤口修复术。患者还接受了60毫克肌内氯胺酮,以产生相对镇静。伤口修复一小时后,患者出现强直-结肠全身性癫痫发作,属于癫痫持续状态。抽搐给予苯二氮卓类药物治疗,患者无并发症出院。结论:利多卡因可引起癫痫持续状态。虽然患者通常没有严重并发症,但遵守安全规程可以防止这些事件的发生。
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A case of status epilepticus due to topical lidocaine toxicity: A case-report and review the literatures
Introduction: Lidocaine hydrochloride is an acetamide derivative that was first introduced by Nils Löfgrene during 1943. It is a local anesthetic agent that is widely used in order to prepare patient for repairing lacerations in everyday practice. Neurological toxicities have been reported with systemic and topical lidocaine. Case Presentation: An 8-year-old female child was reported with a pure laceration who developed status epilepticus after receiving lidocaine along with ketamine. The patient had no medical history of epilepsy or allergic reaction and had a normal physical and mental development status. She received 200 mg lidocaine without epinephrine and underwent wound repair. The patient also received 60 mg of intramuscular ketamine in order to produce a relative sedation. After an hour of wound repair, she developed a tonic-colonic generalized seizure representative of status epilepticus seizure. The convulsions were managed by benzodiazepines, the patient was discharged without complication. Conclusion: Status epilepticus can happen due to lidocaine. Although patients usually recover with no major complications, obeying safety protocols can prevent these events.
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