血清白细胞介素-6和肿瘤坏死因子- α水平在胆囊癌诊断和预后中的初步研究

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL Journal of Laboratory Physicians Pub Date : 2023-08-24 DOI:10.1055/s-0043-1772772
Poonam Sharma, Sarath Krishnan M P, Amit Gupta, Sweety Gupta, R. Saxena, A. Mirza, B. Goyal
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引用次数: 0

摘要

抽象目标 白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)是在肿瘤发生中起主要作用的促炎细胞因子。这些生物标志物在胆囊癌症(GBC)中的诊断和预后实用性相对未被探索。材料和方法 共招募了40名健康对照和40名GBC患者。测量血清IL-6和TNF-α水平,并使用受试者操作特征(ROC)曲线分析其诊断效用。还评估了临床病理变量与血清肿瘤标志物(CEA、CA125和CA19-9)在识别GBC患者中的关系。后果 GBC组血清IL-6和TNF- = 0.0001)。ROC分析显示,血清IL-6和TNF-α的曲线下面积分别为0.89和0.71。在10.34 pg/mL的最佳临界值下,血清IL-6的敏感性和特异性分别为82.5%和97.5%;对于TNF-α,在0.24pg/mL的临界值下,它们分别为40.0%和100%。可切除和不可切除GBC组的血清IL-6水平也存在显著差异。血清IL-6与CA125呈正相关(r = 0.34,p < 0.05),而血清TNF-α与血清肿瘤标志物(CEA、CA125和CA19-9)之间没有观察到相关性。结论 血清IL-6可以作为诊断标志物和可切除性的预测指标,它可以与GBC的其他血清肿瘤标志物联合使用。
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Serum Levels of Interleukin-6 and Tumor Necrosis Factor-Alpha in Diagnosis and Prognosis of Gallbladder Cancer: A Pilot Study
Abstract Objectives  Interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) are proinflammatory cytokines that play a major role in tumorigenesis. These biomarkers are relatively unexplored in gallbladder cancer (GBC) for their diagnostic and prognostic utility. Material and Methods  A total of 40 healthy controls and 40 GBC patients were recruited. Serum IL-6 and TNF-α levels were measured, and their diagnostic utility was analyzed using the receiver operating characteristics (ROC) curve. The relationship between clinicopathological variables and serum tumor markers (CEA, CA125, and CA19-9) in identifying GBC patients was also assessed. Results  Serum IL-6 and TNF-α expression were significantly higher in the GBC group (for both IL-6 and TNF-α, p  = 0.0001) than in healthy controls. ROC analysis revealed that the areas under the curve for serum IL-6 and TNF-α were 0.89 and 0.71, respectively. The sensitivity and specificity for serum IL-6 were 82.5 and 97.5%, respectively, at an optimal cutoff value of 10.34 pg/mL; for TNF-α, they were 40.0 and 100%, respectively, at a cutoff value of 0.24 pg/mL. There was also a significant difference in serum IL-6 levels between the resectable and nonresectable GBC groups. Serum IL-6 showed a positive correlation with CA125 ( r  = 0.34, p  < 0.05), while no correlation was observed between serum TNF-α and serum tumor markers (CEA, CA125, and CA19-9). Conclusion  Serum IL-6 may serve as a diagnostic marker and a predictor of resectability, and it can be used in conjunction with other serum tumor markers in GBC.
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来源期刊
Journal of Laboratory Physicians
Journal of Laboratory Physicians MEDICINE, GENERAL & INTERNAL-
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发文量
99
审稿时长
31 weeks
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