Efficacy of various proton-pump inhibitors and calcium hydroxide as intracanal medicaments against Enterococcus Faecalis: An in vitro study

Aim: The purpose of this study was to compare the efficacy of four proton-pump inhibitors (PPIs) (pantoprazole, omeprazole, lansoprazole, and rabeprazole) when combined with calcium hydroxide and used as intracanal medicaments against Enterococcus faecalis. Methods: A total of 550 microliters of E. faecalis strain was inoculated into two mixtures 6.25 μg/ml and 25 μg/ml containing calcium hydroxide (concentration 16 mg/ml) and PPIs (concentration 1 mg/ml). The efficacy was evaluated by comparing the optical density of the mixtures at 630 nm with two time parameters of 18 h and 24 h. Results: At 18 h, O6 (calcium hydroxide and omeprazole 6.25 μg/ml) showed the maximum percentage inhibition of E. faecalis strain and R25 (calcium hydroxide and rabeprazole 25 μg/ml) showed the least inhibition. At 24-h time interval, O6 showed the maximum inhibition, while R6 (calcium hydroxide and rabeprazole 6.25 μg/ml) showed the least inhibition of E. faecalis strain. Conclusion: The use of PPIs with calcium hydroxide did show promising results and the combination could be used successfully as an intracanal medicament.