{"title":"氯德里滨联合依班膦酸盐成功治疗毛细胞白血病相关骨溶解","authors":"E. Ranković, A. Balenović, S. Dotlic, I. Aurer","doi":"10.46527/2582-5038.170","DOIUrl":null,"url":null,"abstract":"Hairy cell leukemia (HCL) is a rare indolent lymphoproliferative disorder clinically characterized by pancytopenia and splenomegaly [1], with high overall survival rates after treatment with purine analogues [2-4]. We report a relatively young patient with HCL presenting with widespread osteolytic disease detected by PET who was successfully treated with cladribine and ibandronate. Osteolyses are not considered a frequent complication of HCL [5] and we are aware of only one case report describing the use of PET for diagnostic purposes in this setting [6]. Resolution of bone lesions has been described after treatment with radiotherapy or cladribine [6-9], but to our knowledge, there are no data on the use of bisphosphonates in this context.","PeriodicalId":50646,"journal":{"name":"ACM Sigcomm Computer Communication Review","volume":" ","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2020-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hairy Cell Leukemia Related Osteolyses Detected by PET Successfully Treated with Cladribine and Ibandronate\",\"authors\":\"E. Ranković, A. Balenović, S. Dotlic, I. Aurer\",\"doi\":\"10.46527/2582-5038.170\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Hairy cell leukemia (HCL) is a rare indolent lymphoproliferative disorder clinically characterized by pancytopenia and splenomegaly [1], with high overall survival rates after treatment with purine analogues [2-4]. We report a relatively young patient with HCL presenting with widespread osteolytic disease detected by PET who was successfully treated with cladribine and ibandronate. Osteolyses are not considered a frequent complication of HCL [5] and we are aware of only one case report describing the use of PET for diagnostic purposes in this setting [6]. Resolution of bone lesions has been described after treatment with radiotherapy or cladribine [6-9], but to our knowledge, there are no data on the use of bisphosphonates in this context.\",\"PeriodicalId\":50646,\"journal\":{\"name\":\"ACM Sigcomm Computer Communication Review\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2020-11-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACM Sigcomm Computer Communication Review\",\"FirstCategoryId\":\"94\",\"ListUrlMain\":\"https://doi.org/10.46527/2582-5038.170\",\"RegionNum\":4,\"RegionCategory\":\"计算机科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"COMPUTER SCIENCE, INFORMATION SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACM Sigcomm Computer Communication Review","FirstCategoryId":"94","ListUrlMain":"https://doi.org/10.46527/2582-5038.170","RegionNum":4,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"COMPUTER SCIENCE, INFORMATION SYSTEMS","Score":null,"Total":0}
Hairy Cell Leukemia Related Osteolyses Detected by PET Successfully Treated with Cladribine and Ibandronate
Hairy cell leukemia (HCL) is a rare indolent lymphoproliferative disorder clinically characterized by pancytopenia and splenomegaly [1], with high overall survival rates after treatment with purine analogues [2-4]. We report a relatively young patient with HCL presenting with widespread osteolytic disease detected by PET who was successfully treated with cladribine and ibandronate. Osteolyses are not considered a frequent complication of HCL [5] and we are aware of only one case report describing the use of PET for diagnostic purposes in this setting [6]. Resolution of bone lesions has been described after treatment with radiotherapy or cladribine [6-9], but to our knowledge, there are no data on the use of bisphosphonates in this context.
期刊介绍：
Computer Communication Review (CCR) is an online publication of the ACM Special Interest Group on Data Communication (SIGCOMM) and publishes articles on topics within the SIG''s field of interest. Technical papers accepted to CCR typically report on practical advances or the practical applications of theoretical advances. CCR serves as a forum for interesting and novel ideas at an early stage in their development. The focus is on timely dissemination of new ideas that may help trigger additional investigations. While the innovation and timeliness are the major criteria for its acceptance, technical robustness and readability will also be considered in the review process. We particularly encourage papers with early evaluation or feasibility studies.
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