重要先天细胞在哮喘中的作用简介

Tao Wang, Zhihong Feng, Bing Wei, Lin Zhang, N. Xia, Xiuhong Nie
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引用次数: 0

摘要

哮喘是一种气道多因素紊乱的慢性炎症性疾病,与T辅助型2(TH2)细胞有关。它被认为是先天细胞和结构细胞之间复杂相互作用的结果,包括树突状细胞(DC)、上皮细胞、肥大细胞(MC)、嗜碱性粒细胞、嗜酸性粒细胞和第2组先天淋巴细胞(ILC2),后者最终在哮喘的发病机制中维持Th2免疫。在这篇叙述性综述中,讨论了重要的先天细胞对哮喘的作用细节,以促进未来对哮喘的研究。
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Brief Introduction of Important Innate Cells in Roles of Asthma
Asthma is a chronic inflammatory disease with multifactorial disorder of the airways, and was associated with T helper type 2 (TH2) cells. It is considered the results of complicated interactions between innate cells and structural cells, including dendritic cells (DCs), epithelial cells, mast cells (MCs), basophils, eosinophils and group 2 innate lymphoid cells (ILC2s), which finally sustains Th2 immunity in the pathogenesis of asthma. In this narrative review the details of roles of important innate cells against asthma are discussed to facilitate the future study of asthma.
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