A Simple Approach to Predict Spleen Volume in Patients with Splenomegaly Due to Portal Hypertension

Background: Splenomegaly and hypersplenism are common presentations of portal hypertension and can result in severe comorbidities. The degree of splenomegaly is associated with disease severity and has been established as a reliable noninvasive indicator for disease surveillance. Objectives: This study aimed to propose a simple and repeatable splenic measurement model to estimate the splenic volume in patients with portal hypertension. Methods: In total, 161 patients with portal hypertension were admitted to our hospital from March 2017 to August 2020, with a final enrollment of 106 subjects. The splenic volume calculated via IQQA-Liver software was used for reference. Radiological data were retrospectively reviewed to measure the height, length, and width of the spleen. Different volume prediction models were constructed based on statistically significant laboratory and radiological parameters. Results: The average spleen volume measured by the IQQA-Liver software was 852.29±362.26cm3. Model 0 was constructed based on hematological and radiological parameters, while Models 1 and 2 were based on radiological parameters alone. Model 1 was superior to the others according to the Bland-Altman scatterplot and correlation analysis. Conclusion: The proposed estimation model is a reliable predictor for splenic volume, providing valuable information in patients with portal hypertension. The simple technique allows for widespread clinical application