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{"title":"纳米生物材料在抗病毒疫苗佐剂中的应用","authors":"L. Cao, Z. Wang, B. Wang","doi":"10.19894/j.issn.1000-0518.210062","DOIUrl":null,"url":null,"abstract":"Viral infectious diseases seriously endanger human health, the new type of coronary pneumonia has become a major global public safety and health incident. Vaccination is an important way to effectively prevent and control viral infections and the spread of infectious diseases. While routine vaccines have shown a shortfall, such as short half-life, weak immunogenicity, weak targeting, slow absorption, and high storage and delivery requirements. In recent years, nanobiomaterials are expected to be used as vaccine adjuvants for the prevention and treatment of viral infectious diseases due to their lower systemic toxicity, stronger tissue targeting, higher specific surface area and lower immune titer. This review will focus on the classification, action pathways and mechanisms of nanobiomaterials as adjuvants for antiviral vaccines. In addition, the application of nanobiomaterials in the new crown vaccine is described in combination with coronavirus disease-19 (COVID-19), which is currently popular worldwide. Finally, the challenges faced by nanobiomaterials in antiviral vaccine adjuvants are summarized. © 2021, Science in China Press. All rights reserved.","PeriodicalId":9936,"journal":{"name":"应用化学","volume":"38 1","pages":"572-581"},"PeriodicalIF":0.0000,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Application of nano biomaterials in antiviral vaccine adjuvant\",\"authors\":\"L. Cao, Z. Wang, B. Wang\",\"doi\":\"10.19894/j.issn.1000-0518.210062\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Viral infectious diseases seriously endanger human health, the new type of coronary pneumonia has become a major global public safety and health incident. Vaccination is an important way to effectively prevent and control viral infections and the spread of infectious diseases. While routine vaccines have shown a shortfall, such as short half-life, weak immunogenicity, weak targeting, slow absorption, and high storage and delivery requirements. In recent years, nanobiomaterials are expected to be used as vaccine adjuvants for the prevention and treatment of viral infectious diseases due to their lower systemic toxicity, stronger tissue targeting, higher specific surface area and lower immune titer. This review will focus on the classification, action pathways and mechanisms of nanobiomaterials as adjuvants for antiviral vaccines. In addition, the application of nanobiomaterials in the new crown vaccine is described in combination with coronavirus disease-19 (COVID-19), which is currently popular worldwide. Finally, the challenges faced by nanobiomaterials in antiviral vaccine adjuvants are summarized. © 2021, Science in China Press. All rights reserved.\",\"PeriodicalId\":9936,\"journal\":{\"name\":\"应用化学\",\"volume\":\"38 1\",\"pages\":\"572-581\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"应用化学\",\"FirstCategoryId\":\"1087\",\"ListUrlMain\":\"https://doi.org/10.19894/j.issn.1000-0518.210062\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"应用化学","FirstCategoryId":"1087","ListUrlMain":"https://doi.org/10.19894/j.issn.1000-0518.210062","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Application of nano biomaterials in antiviral vaccine adjuvant
Viral infectious diseases seriously endanger human health, the new type of coronary pneumonia has become a major global public safety and health incident. Vaccination is an important way to effectively prevent and control viral infections and the spread of infectious diseases. While routine vaccines have shown a shortfall, such as short half-life, weak immunogenicity, weak targeting, slow absorption, and high storage and delivery requirements. In recent years, nanobiomaterials are expected to be used as vaccine adjuvants for the prevention and treatment of viral infectious diseases due to their lower systemic toxicity, stronger tissue targeting, higher specific surface area and lower immune titer. This review will focus on the classification, action pathways and mechanisms of nanobiomaterials as adjuvants for antiviral vaccines. In addition, the application of nanobiomaterials in the new crown vaccine is described in combination with coronavirus disease-19 (COVID-19), which is currently popular worldwide. Finally, the challenges faced by nanobiomaterials in antiviral vaccine adjuvants are summarized. © 2021, Science in China Press. All rights reserved.
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