Blessing Myke-Mbata, S. Meludu, I. Mba, J. Okwara, M. Olisah
{"title":"尿酸作为2型糖尿病患者心血管疾病危险分层的生物标志物的评价","authors":"Blessing Myke-Mbata, S. Meludu, I. Mba, J. Okwara, M. Olisah","doi":"10.4103/njm.njm_113_22","DOIUrl":null,"url":null,"abstract":"Background: Biomarkers may be needed to aid in the screening of cardiovascular disease (CVD) in diabetes mellitus (DM) to enhance early detection and foster early intervention in the management of chronic complications in DM. Hyperuricemia has been correlated with diabetic cardiovascular complication (CVC) and has been implicated in the development and manifestation of CVDs. Hence, this study intends to evaluate its role in CVD risk stratification among patients DM. Aim: Evaluation of the value of uric acid (UA) in CVDs risk stratification among type 2 diabetics. Patients, Materials and Methods: This is a cross-sectional study made up of 101 type 2 DM and control participants. The diabetics were classified into two groups: depending on the presence or absence of CVCs. The CVC observed were diabetic retinopathy, peripheral neuropathy, cardiovascular accident, and ischemic heart diseases. Blood samples were collected for the determination of glycated hemoglobin and UA. Results: UA increased significantly in diabetics with CVCs and especially among those with peripheral neuropathy and poorly controlled glycemic level. However, the diagnostic measures of UA has a poor ability to distinguish between patients with and without CVD. Conclusion: UA may not be diagnostically relevant in screening for CVDs in the bid to ease early diagnosis among diabetes patients despite its comparative increase among those with CVCs.","PeriodicalId":52572,"journal":{"name":"Nigerian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of uric acid as a biomarker for cardiovascular disease risk stratification among patients with type 2 diabetes mellitus\",\"authors\":\"Blessing Myke-Mbata, S. Meludu, I. Mba, J. Okwara, M. Olisah\",\"doi\":\"10.4103/njm.njm_113_22\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Biomarkers may be needed to aid in the screening of cardiovascular disease (CVD) in diabetes mellitus (DM) to enhance early detection and foster early intervention in the management of chronic complications in DM. Hyperuricemia has been correlated with diabetic cardiovascular complication (CVC) and has been implicated in the development and manifestation of CVDs. Hence, this study intends to evaluate its role in CVD risk stratification among patients DM. Aim: Evaluation of the value of uric acid (UA) in CVDs risk stratification among type 2 diabetics. Patients, Materials and Methods: This is a cross-sectional study made up of 101 type 2 DM and control participants. The diabetics were classified into two groups: depending on the presence or absence of CVCs. The CVC observed were diabetic retinopathy, peripheral neuropathy, cardiovascular accident, and ischemic heart diseases. Blood samples were collected for the determination of glycated hemoglobin and UA. Results: UA increased significantly in diabetics with CVCs and especially among those with peripheral neuropathy and poorly controlled glycemic level. However, the diagnostic measures of UA has a poor ability to distinguish between patients with and without CVD. Conclusion: UA may not be diagnostically relevant in screening for CVDs in the bid to ease early diagnosis among diabetes patients despite its comparative increase among those with CVCs.\",\"PeriodicalId\":52572,\"journal\":{\"name\":\"Nigerian Journal of Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nigerian Journal of Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/njm.njm_113_22\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nigerian Journal of Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/njm.njm_113_22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Evaluation of uric acid as a biomarker for cardiovascular disease risk stratification among patients with type 2 diabetes mellitus
Background: Biomarkers may be needed to aid in the screening of cardiovascular disease (CVD) in diabetes mellitus (DM) to enhance early detection and foster early intervention in the management of chronic complications in DM. Hyperuricemia has been correlated with diabetic cardiovascular complication (CVC) and has been implicated in the development and manifestation of CVDs. Hence, this study intends to evaluate its role in CVD risk stratification among patients DM. Aim: Evaluation of the value of uric acid (UA) in CVDs risk stratification among type 2 diabetics. Patients, Materials and Methods: This is a cross-sectional study made up of 101 type 2 DM and control participants. The diabetics were classified into two groups: depending on the presence or absence of CVCs. The CVC observed were diabetic retinopathy, peripheral neuropathy, cardiovascular accident, and ischemic heart diseases. Blood samples were collected for the determination of glycated hemoglobin and UA. Results: UA increased significantly in diabetics with CVCs and especially among those with peripheral neuropathy and poorly controlled glycemic level. However, the diagnostic measures of UA has a poor ability to distinguish between patients with and without CVD. Conclusion: UA may not be diagnostically relevant in screening for CVDs in the bid to ease early diagnosis among diabetes patients despite its comparative increase among those with CVCs.
期刊介绍:
The Nigerian Journal of Medicine publishes articles on socio-economic, political and legal matters related to medical practice; conference and workshop reports and medical news.