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{"title":"李氏人工肝系统的研制及临床应用","authors":"Xiao-wei Xu","doi":"10.3760/CMA.J.ISSN.1000-6680.2019.09.002","DOIUrl":null,"url":null,"abstract":"肝衰竭病情进展快，病死率高。李氏人工肝自1986年起发展至今，逐步形成了独特且疗效显著的治疗体系，被广泛应用于肝衰竭的救治。李氏人工肝治疗模式各有特点，新型李氏人工肝系统(Li′s artificial liver system, Li-ALS)集成血浆置换、血浆灌流和血液滤过等各种净化手段，提供了肝衰竭同质化治疗方案。选择人工肝治疗时机，筛选人工肝相关生物标志物及联合新的肝衰竭治疗手段是李氏人工肝潜在的发展方向。","PeriodicalId":10127,"journal":{"name":"中华传染病杂志","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Development and clinical application of Li's Artificial Liver System\",\"authors\":\"Xiao-wei Xu\",\"doi\":\"10.3760/CMA.J.ISSN.1000-6680.2019.09.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"肝衰竭病情进展快，病死率高。李氏人工肝自1986年起发展至今，逐步形成了独特且疗效显著的治疗体系，被广泛应用于肝衰竭的救治。李氏人工肝治疗模式各有特点，新型李氏人工肝系统(Li′s artificial liver system, Li-ALS)集成血浆置换、血浆灌流和血液滤过等各种净化手段，提供了肝衰竭同质化治疗方案。选择人工肝治疗时机，筛选人工肝相关生物标志物及联合新的肝衰竭治疗手段是李氏人工肝潜在的发展方向。\",\"PeriodicalId\":10127,\"journal\":{\"name\":\"中华传染病杂志\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华传染病杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1000-6680.2019.09.002\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华传染病杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1000-6680.2019.09.002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Liver failure progresses rapidly and has a high mortality rate. Since its development in 1986, Li's artificial liver has gradually formed a unique and highly effective treatment system, which is widely used in the treatment of liver failure. The Li's artificial liver system (Li ALS) integrates various purification methods such as plasma exchange, plasma perfusion, and hemofiltration, providing a homogeneous treatment plan for liver failure. Choosing the timing of artificial liver treatment, screening biomarkers related to artificial liver, and combining them with new treatment methods for liver failure are potential development directions for Li's artificial liver.
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