体外转体内

IF 4.6 Current opinion in toxicology Pub Date : 2020-10-01 DOI:10.1016/j.cotox.2020.09.001

William B. Mattes

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引用次数: 11

摘要

体外研究的科学在过去的100年里取得了巨大的进步，特别是在毒理学方面的应用。最近的发展，如体外三维培养和微生理系统，提供了更大的复制体内功能的希望。尽管如此，验证系统性能并推断其对动物或人类反应的挑战仍然存在

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In vitro to in vivo translation

The science of in vitro studies has advanced dramatically over the last 100 years, particularly in regards to their application in toxicology. Recent developments such as in vitro three-dimensional cultures and microphysiological systems have offered the promise of even greater replication of in vivo function. Nonetheless, the challenge of validating a system's performance and extrapolating it's responses to those of an animal or human remains

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