马尾莲叶水醇提取物的抗糖尿病作用及慢性毒性研究

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Pharmacognosy Research Pub Date : 2023-02-22 DOI:10.5530/pres.15.2.034
B. Heredia-Mercado, F. Delgado-Vargas, L. U. Osuna-Martínez, E. Noguera-Corona, J. López-Valenzuela, R. Ramos-Payán, G. López-Angulo
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引用次数: 0

摘要

背景:刺五加提取物具有重要的生物活性,对人体健康具有重要意义。然而,体内对葡萄糖水平的影响和慢性毒性尚不清楚。目的:分析枯草芽孢杆菌水醇提取物(HE–Es)在BALB/c小鼠体内的降血糖和抗高血糖作用(50、100和200 mg/kg体重)以及慢性毒性(1000 mg/kg体重,持续270天)。材料与方法:采用高效液相色谱法对HE–Es进行分析。测量血糖水平以确定对血糖的影响。毒性试验中记录了不同的参数:例如,饲料消耗、外观/行为、生化和血液学参数以及肝脏和肾脏组织学。结果:槲皮素-3-O-β-葡萄糖苷和异鼠李素-3-O-β葡萄糖苷是HE–Es中的主要黄酮类化合物。HE–Es(200 mg/kg体重,49.1%)和格列本脲(10 mg/kg体重,52%)治疗可降低血糖。比较抗高血糖活性,HE–Es(100 mg/kg体重,29.32%;200 mg/kg体重,28.99%)和阿卡波糖(10 mg/kg体重,19.87%)的治疗效果相似。另一方面,HE–Es在小鼠中是无害的(LD 50>1000 mg/kg b.w.),结果表明,HE–Es具有适应和免疫刺激活性。肝肾组织学正常;然而,雄性小鼠表现出零级脂肪变性,在停药后在HE–Es卫星中消失。结论:本研究首次报道了HE–Es对血糖水平的体内影响和景天科植物的慢性毒性,支持了HE–Es的抗糖尿病潜力和安全性。未来的研究必须证实HE–Es对人类的影响,使其能够用于高价值的配方中。
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Antidiabetic Potential and Chronic Toxicity of Hydroalcoholic Extract of Echeveria subrigida Leaves
Background: Echeveria subrigida extracts have biological activities of human health importance. However, the in vivo effects on glucose levels and chronic toxicity are unknown. Objectives: To analyse the in vivo hypoglycemic and antihyperglycemic effects (50, 100, and 200 mg/kg b.w.) and chronic toxicity (1000 mg/kg b.w. for 270 days) of the hydroalcoholic extract of E. subrigida (HE–Es) in BALB/c mice. Materials and Methods: The HE–Es was analysed by HPLC. Glucose levels were measured to establish the effects on glycemia. Different parameters were registered in the toxicity assay: e.g. , feed consumption, appearance/behaviour, biochemical and haematological parameters and liver and kidney histologies. Results: Quercetin–3-O -β-glucoside and isorhamnetin–3-O -β-glucoside were the main flavonoids in the HE–Es. Glycemia was reduced by the HE–Es (200 mg/kg b.w., 49.1%) and glibenclamide (10 mg/kg b.w., 52%) treatments. Comparing the antihyperglycemic activities, similar reductions were found between HE–Es (100 mg/kg b.w., 29.32%; 200 mg/kg, 28.99%) and acarbose (10 mg/kg b.w., 19.87%) treatments. On the other hand, the HE–Es was innocuous in mice (LD 50 > 1000 mg/kg b.w.), and the results suggested that HE–Es had adaptogenic, and immunostimulant activities. The hepatic and renal histologies were normal; however, male mice showed level zero steatosis that disappeared in the HE–Es satellite after treatment withdrawal. Conclusion: This study reports for the first time the in vivo effects on blood glucose levels of HE–Es and chronic toxicity of a Crassulaceae plant, supporting the antidiabetic potential and safety of HE–Es. Future studies must corroborate the effects of HE–Es in humans, allowing its use in high-value formulations.
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Pharmacognosy Research
Pharmacognosy Research PHARMACOLOGY & PHARMACY-
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期刊介绍: Pharmacognosy Research [ISSN: Print -0976-4836, Online - 0974-8490] [http://www.phcogres.com], Quarterly a publication of Phcog.Net is published by Wolters Kluwer - Medknow Publications. It provides peer-reviewed original research articles from the field of Natural Products. The journal serves an international audience of scientists and researchers in a variety of research and academia by quickly disseminating research findings related to Medicinal Plants and Natural Products. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submissions of original contributions in all areas of pharmacognosy are welcome.
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