脑转移瘤切除后内眼角恶性黑色素瘤的长期生存及易普利木单抗治疗

IF 1.1 Q4 ALLERGY Journal of Cutaneous Immunology and Allergy Pub Date : 2022-07-15 DOI:10.1002/cia2.12268

Masahito Yasuda MD, PhD, Akihito Uehara MD, PhD, Shintaro Saito MD, Yuko Kuriyama MD, PhD, Kazuya Yamada MD, PhD, Aina Oka MD, Marie Miyagawa MD, Osamu Ishikawa MD, PhD, Sei-Ichiro Motegi MD, PhD

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摘要

远处转移的恶性黑色素瘤最近已经用免疫检查点抑制剂(ICIs)或BRAF抑制剂治疗。这些抑制剂能够改善恶性黑色素瘤的预后。然而，脑转移患者的预后仍然很差一名45岁日本女性于4年前内眼角出现黑色结节并逐渐增大。体格检查显示一个30 × 27毫米大小，淡红色到黑紫色的结节，呈息肉状突起，伴周围毛细血管扩张(图1A)。我们临床诊断为恶性黑色素瘤。FDGPET未发现淋巴结及远处转移。切除肿瘤1厘米边缘，行前哨淋巴结活检。病理表现为非典型肿瘤细胞

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Malignant melanoma of inner canthus with long-term survival after resection of brain metastasis and treatment with ipilimumab

Cerebellar metastasis from malignant melanoma of the inner canthus was resected. The patient was subsequently treated with ipilimumab and has remained disease-free 6 years, however, developed sarcoidosis.

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