奥密克戎如何以及为什么不如严重急性呼吸系统综合征冠状病毒2型严重的科学观点

Rachel Parise, S. Ramesh, Jun Ren, Manoj Govindarajulu, Rishi M. Nadar, Suhrud Pathak, Timothy Moore, M. Dhanasekaran
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摘要

摘要奥密克戎目前是严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的主要变种,该冠状病毒是2019冠状病毒病(新冠肺炎)大流行的罪魁祸首。奥密克戎与轻微症状有关,尽管它可能对高危患者群体造成有害影响。奥密克戎和新冠肺炎影响多个器官系统,包括呼吸系统、胃肠道、心血管系统、中枢神经系统、眼科系统、泌尿生殖道和肌肉骨骼系统。新冠肺炎感染其他器官系统,包括血液系统、胆道系统、肾系统和皮肤系统。将病毒诱导的并发症进行比较,以讨论奥密克戎与真正的严重急性呼吸系统综合征冠状病毒2型病毒的影响,揭示奥密克龙的危害较小。此外,新冠肺炎更有可能感染老年人、男性和轻度至重度症状的肥胖者。奥密克戎在年轻人群和超重女性中引起轻微症状。数据是通过PubMed、疾病预防和控制中心以及世界卫生组织获得的。导致器官系统相关并发症的新冠肺炎和奥密克戎机制可能是因为对活跃感染的自然免疫反应、导致细胞因子释放综合征的细胞因子的不可控释放,以及通过血管紧张素转化酶2/跨膜丝氨酸蛋白酶2受体结合和进入宿主细胞进行感染而导致的直接病毒损伤。
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A scientific perspective of how and why Omicron is less severe than SARS-CoV-2
Abstract Omicron is currently the dominant variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the coronavirus responsible for the coronavirus disease 2019 (COVID-19) pandemic. Omicron is associated with mild symptoms, although it can cause harmful effects in high-risk patient populations. Omicron and COVID-19 affect multiple organ systems, including the respiratory system, gastrointestinal tract, cardiovascular system, central nervous system, ophthalmic system, genitourinary tract, and musculoskeletal system. COVID-19 infects additional organ systems, including the hematological system, hepatobiliary system, renal system, and dermatologic system. The viral-induced complications were compared to discuss the effects of Omicron versus the authentic SARS-CoV-2 virus, revealing less detrimental outcomes for Omicron. Moreover, COVID-19 is more likely to infect older adults, males, and obesity with mild to severe symptoms. Omicron causes mild symptoms in younger populations and overweight females. Data were acquired using PubMed, Centers for Disease Prevention and Control, and the World Health Organization. COVID-19 and Omicron mechanisms causing organ system-related complications are likely because of the natural immune response to the active infection, the uncontrollable release of cytokines causing cytokine release syndrome, and direct viral damage through angiotensin-converting enzyme 2/transmembrane serine protease 2 receptor binding and entrance to the host cell for infection.
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