471. 怀疑肿瘤浸润行微创食管切除术并切除降主动脉

IF 2.3 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Diseases of the Esophagus Pub Date : 2023-08-30 DOI:10.1093/dote/doad052.253
M. Menéndez, M. Bruna, J. Vaqué, Nuria García Del Olmo, Fernando Mingol Navarro, M.L. Nieto
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引用次数: 0

摘要

传统上,食道肿瘤的生存率很低,因为那些浸润主动脉、气道或椎骨的T4b肿瘤尽管没有远处病变,但无法切除。随着手术技术的进步,新辅助/辅助系统治疗的完善以及多学科治疗方法的发展,这些不可切除的障碍正在逐渐被打破。这是一位68岁的患者,每天抽一包烟,在距牙弓30厘米处出现鳞状细胞癌,根据CROSS方案进行了放化疗。在另一中心手术后,怀疑降主动脉浸润,因此他被转介到我中心。多学科委员会对该病例进行了讨论,并决定将TEVAR置于第一阶段,手术切除病变置于第二阶段。患者行三期食管切除术(McKeown),手术采用俯卧胸腔镜,无选择性插管,在怀疑有肿瘤浸润的降主动脉前壁行全淋巴结切除和整体切除的调节食管切除术。露出主动脉假体(图2)。将假体覆盖在心包上,将其与可能的感染源隔离,并将其与主动脉壁松散缝合和生物胶固定。采用纵隔胃成形术和颈部环形机械吻合术重建。术后以宫颈渗漏为特征,经保守治疗得以解决。在没有全身性疾病的食管肿瘤疑似肿瘤浸润的情况下,只要在专门从事复杂食管切除术的中心和包括心脏外科医生在内的多学科团队中进行,采用主动脉补片的微创方法切除可能是一种安全的治疗选择。肿瘤预后必须进行长期评估,但实现R0切除不应比局部晚期可切除的肿瘤差。
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471. MINIMALLY INVASIVE ESOPHAGECTOMY WITH RESECTION OF THE DESCENDING AORTA DUE TO SUSPECTED TUMOR INFILTRATION
Classically, esophageal neoplasms have had a poor survival, considering those T4b tumors that infiltrate the aorta, airways or vertebrae to be unresectable despite not having distant disease. With the advancement of surgical techniques, the improvement of neoadjuvant/adjuvant systemic treatments and the multidisciplinary approach to this pathology, these barriers of unresectability are gradually being broken. This is a 68-year-old patient, a 1-pack-a-day smoker, who presented squamous cell carcinoma 30 cm from the dental arch treated with chemoradiotherapy according to the CROSS scheme. After surgery at another center, there is suspicion of infiltration of the descending aorta, for which he was referred to our center. The case is discussed in a multidisciplinary committee and a decision is made to place TEVAR in the first stage and surgical resection of the lesion in a second stage. The patient underwent surgery performing a three-stage esophagectomy (McKeown) using prone thoracoscopy without selective intubation, through which a regulated esophagectomy was performed with total lymphadenectomy and en bloc resection along with the anterior wall of the descending aorta where there was suspicion of tumor infiltration, exposing the aortic prosthesis (Photo 2). The prosthesis is covered to isolate it from possible sources of infection with a patch of pericardium fixed with loose sutures to the aortic wall and biological glue. It was reconstructed using a mediastinal gastroplasty with cervical circular mechanical anastomosis. Postoperative period marked by cervical leakage that was resolved by conservative treatment. Resection using a minimally invasive approach of an aortic patch in cases of suspected tumor infiltration in esophageal neoplasms without systemic disease may be a safe therapeutic option as long as it is performed in centers specialized in complex esophageal resections and with a multidisciplinary team that also involves cardiac surgeons. The oncological prognosis must be evaluated in the long term, but achieving R0 resections should not be worse than in locally advanced resectable tumors.
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来源期刊
Diseases of the Esophagus
Diseases of the Esophagus 医学-胃肠肝病学
CiteScore
5.30
自引率
7.70%
发文量
568
审稿时长
6 months
期刊介绍: Diseases of the Esophagus covers all aspects of the esophagus - etiology, investigation and diagnosis, and both medical and surgical treatment.
期刊最新文献
395. SURGICAL PROCEDURE AND PERIOPERATIVE OUTCOME OF TRANSMEDIASTINAL ESOPHAGECTOMY FOR ESOPHAGOGASTRIC JUNCTION CANCER 471. MINIMALLY INVASIVE ESOPHAGECTOMY WITH RESECTION OF THE DESCENDING AORTA DUE TO SUSPECTED TUMOR INFILTRATION 434. INCREASING TUMOUR INFILTRATING LYMPHOCYTES THROUGH EXERCISE ALONE—A PILOT RCT IN ESOPHAGEAL ADENOCARCINOMA 465. COMPLETE RESPONSE IN BARRETT’S HIGH-GRADE DYSPLASIA WITH THE UTILISATION OF RADIOFREQUENCY ABLATION: A SYSTEMATIC REVIEW 348. IDENTIFYING NOVEL MOLECULAR SUBTYPES OF ESOPHAGEAL ADENOCARCINOMA USING LASER CAPTURE MICRODISSECTED RNA-SEQ SAMPLES
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