壳聚糖对顺铂肝肾毒性的影响

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Istanbul Medical Journal Pub Date : 2022-08-01 DOI:10.4274/imj.galenos.2022.54077

A. Aykaç, Hüseyin Şah, A. Kükner, S. Sayıner, A. Sehirli

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引用次数: 0

摘要

CTS治疗可逆转肾和肝组织的肝肾损伤（p＜0.05）。总的来说，CIS诱导的凋亡参数Bcl-2/Bax比值和胱天蛋白酶-3表达的增加可被CTS治疗逆转（p＜0.01）。结论：CTS作为一种生物聚合物，可能通过预防CIS引起的肝肾损伤而具有保护作用。摘要

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Effects of Chitosan on Cisplatin-Induced Hepatorenal Toxicity in an Animal Model

hepatorenal damage was reversed with CTS treatment in the renal and hepatic tissues (p<0.05). Overall, CIS-induced increases in apoptotic parameters, Bcl-2/Bax ratio and caspase-3 expression, were reversed by CTS treatment (p<0.05). Conclusion: It was determined that CTS, a biopolymer, may have a protective effect by preventing hepatorenal damage caused by CIS. ABSTRACT

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