药品中过量泛醇对映体的光谱化学测定

IF 0.9 Q4 CHEMISTRY, MULTIDISCIPLINARY Acta Chimica Slovaca Pub Date : 2020-10-01 DOI:10.2478/acs-2020-0020
R. Poláček, A. Kleinová, P. Májek
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引用次数: 1

摘要

泛醇具有抗菌、舒缓和愈合的特性,广泛应用于各种医药和化妆品中。只有D-蒽醇具有生物活性,而其L-形式可能抵消D-对映体的生物活性。两种对映体都具有保湿和保湿作用。因此,有必要开发一种快速、廉价的测定药物制剂中泛醇对映体过量的方法。在本研究中,β-环糊精被用作手性选择器来识别泛醇对映体。通过化学计量评估,b-环糊精和分析物形成的包合物在NIR和UV/VIS光谱中显示出较小的差异。基于优值和模型特性,优选在所选近红外光谱范围内的PLS校准模型。与近红外光谱法相比,紫外/可见光谱法具有样品制备复杂的缺点。两种方法得出的结果基本一致。对结果的统计调查(通过Student t检验和Fisher F检验)证实,所提出的方法具有可比性,适用于泛醇药物制剂的手性分析。
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Spectro-chemometric determination of panthenol enantiomeric excess in pharmaceutical products
Abstract Antibiotic, soothing and healing properties of panthenol are exploited in various pharmaceutical and cosmetic products. Only D-panthenol is biologically active while its L-form might counteract the biological effectiveness of the D-enantiomer. Hydrating and moisturizing effects are exhibited by both enantiomers. Therefore, it is necessary to develop a rapid and cheap method for the determination of panthenol enantiomeric excess in pharmaceutical preparations. In this study, b-cyclodextrin was used as a chiral selector for the recognition of panthenol enantiomers. Inclusion complexes formed by b-cyclodextrin and the analyte showed small differences in NIR and UV/VIS spectra compared by chemometric assessment. Based on the figure of merit and model characteristics, PLS calibration model in the selected range of NIR spectra is preferred. UV/VIS spectrometry has the disadvantage of complicated sample preparation compared to NIR spectrometry. Results reached by both proposed methods were in good agreement. Statistical investigation of the results (by Student t-test and Fisher F-test) confirmed that the proposed methods are comparable and applicable to chiral analysis of panthenol pharmaceutical preparations.
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来源期刊
Acta Chimica Slovaca
Acta Chimica Slovaca CHEMISTRY, MULTIDISCIPLINARY-
自引率
12.50%
发文量
11
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