C. Yuan, B. Jiang, Xiaocui Xu, Yunjie Wan, Li Wang, Jia Chen
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Anti-human ovarian cancer and cytotoxicity effects of nickel nanoparticles green-synthesized by Alhagi maurorum leaf aqueous extract
Abstract Alhagi maurorum (camelthorn) is one of the popular medicinal plants. The plant has many pharmaceutical uses in traditional medicine. In this study, nickel nanoparticles were synthesized according to green chemistry rules using the aqueous extract of A. maurorum. The green-synthesized NiNPs were characterized using different techniques such as EDX, FE-SEM, XRD, UV–vis and FT-IR. The FE-SEM results confirm spherical morphology for the nanoparticles with size of 20.56–36.63 nm. In the oncological part of the present study, the treated cells with NiNPs were assessed by MTT assay for 48 h about the cytotoxicity and anti-human ovarian cancer properties on normal (HUVEC) and ovarian cancer cell lines i.e. OVCAR-3, ES-2, TOV-21G, OV-90 and UWB1.289. The viability of malignant ovarian cell lines reduced dose-dependently in the presence of NiNPs. The IC50 of NiNPs was 191, 312, 250, 396 and 241 µg/mL against OVCAR-3, ES-2, TOV-21G, OV-90 and UWB1.289 cell lines respectively.
期刊介绍：
Journal of Experimental Nanoscience, an international and multidisciplinary journal, provides a showcase for advances in the experimental sciences underlying nanotechnology and nanomaterials.
The journal exists to bring together the most significant papers making original contributions to nanoscience in a range of fields including biology and biochemistry, physics, chemistry, chemical, electrical and mechanical engineering, materials, pharmaceuticals and medicine. The aim is to provide a forum in which cross fertilization between application areas, methodologies, disciplines, as well as academic and industrial researchers can take place and new developments can be encouraged.
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