钙蛋白酶与口腔癌——一种检测癌细胞侵袭的新方法

Sayani Shome, Shiladitya Sil
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引用次数: 0

摘要

钙蛋白酶是一种依赖于Ca2+的非溶酶体细胞质和线粒体半胱氨酸蛋白酶,存在于人类和其他哺乳动物的组织和器官中。它是口腔鳞状细胞癌(OSCC)中癌细胞增殖和侵袭的启动剂,也是细胞凋亡的调节剂。下面的文章基于以往和正在进行的研究,对这种新分子进行了简要的回顾。
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Calpain and oral cancer – A novel approach to detect cancer cell invasion
Calpain is a Ca2+ dependent non-lysosomal cytosolic and mitochondrial cysteine protease found in tissue and organ specific manner in human being and in other mammals. It is observed to be an initiator for cancer cell propagation and invasion in Oral Squamous Cell Carcinoma (OSCC) and also a regulator of apoptosis. A concised review on this novice molecule is re-explored based on previous and ongoing studies in the following article.
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