Aboh Iku Kisani, Ageh Nonye Immaculate, Saganuwan Alhaji Saganuwan
{"title":"利多卡因、利多卡因-肾上腺素和田麻水提取物在犬阉割过程中的局部麻醉活性比较","authors":"Aboh Iku Kisani, Ageh Nonye Immaculate, Saganuwan Alhaji Saganuwan","doi":"10.1007/s13596-022-00655-1","DOIUrl":null,"url":null,"abstract":"<div><p>Lignocaine is a local anaesthetic used in castration of dogs. However, lignocaine is sometimes combined with adrenaline in order to prolong the anaesthetic effect. Either lignocaine or lignocaine-adrenaline combination is associated with toxicity effects. Hence, anaesthetic potentials of lignocaine, lignocaine-adrenaline, fruit and stem-bark aqueous extract of <i>Annona muricata</i> were comparatively studied during castration in Nigerian indigenous dogs. Twelve adult dogs of about 1.00 ± 0.00-year-old and weighing 8.8 ± 0.4 kg divided into four groups of three each were used. The four groups were administered 2% lignocaine, lignocaine-adrenaline, fruit and stem-bark aqueous extracts each, at a dose of, 7.5 mg/kg each, by infiltration on the scrotal sac. After loss of sensation, ochidectomy was carried out. Time of onset and duration of anaesthesia were significantly higher (<i>p</i> < 0.05) in stem bark and fruit extract groups as compared to lignocaine and lignocaine-adrenaline groups. More so duration of anaesthesia was higher in lignocaine-adrenaline as compared to adrenaline. The findings have shown that lignocaine and lignocaine-adrenaline could increase whereas stem bark and fruit extract could decrease respiratory rate, respectively. Highest duration of anaesthesia was observed in stem- bark extract anaesthetized dogs followed by fruit extract treated group in comparison with lignocaine-adrenaline and lignocaine treated groups. Time of onset of anaesthesia was longest in fruit extract treated group and shortest in lignocaine and lignocaine-adrenaline treated groups respectively. Lignocaine and lignocaine/adrenaline increased and decreased haematological parameters, respectively. Lignocaine, lignocaine-adrenaline and the extracts altered biochemical parameters. Hence, <i>Annona muricata</i> could serve as potent local anaesthetic agent.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparative local anaesthetic activity of lignocaine, lignocaine-adrenaline and water extracts of Annona muricata during castration in dogs\",\"authors\":\"Aboh Iku Kisani, Ageh Nonye Immaculate, Saganuwan Alhaji Saganuwan\",\"doi\":\"10.1007/s13596-022-00655-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Lignocaine is a local anaesthetic used in castration of dogs. However, lignocaine is sometimes combined with adrenaline in order to prolong the anaesthetic effect. Either lignocaine or lignocaine-adrenaline combination is associated with toxicity effects. Hence, anaesthetic potentials of lignocaine, lignocaine-adrenaline, fruit and stem-bark aqueous extract of <i>Annona muricata</i> were comparatively studied during castration in Nigerian indigenous dogs. Twelve adult dogs of about 1.00 ± 0.00-year-old and weighing 8.8 ± 0.4 kg divided into four groups of three each were used. The four groups were administered 2% lignocaine, lignocaine-adrenaline, fruit and stem-bark aqueous extracts each, at a dose of, 7.5 mg/kg each, by infiltration on the scrotal sac. After loss of sensation, ochidectomy was carried out. Time of onset and duration of anaesthesia were significantly higher (<i>p</i> < 0.05) in stem bark and fruit extract groups as compared to lignocaine and lignocaine-adrenaline groups. More so duration of anaesthesia was higher in lignocaine-adrenaline as compared to adrenaline. The findings have shown that lignocaine and lignocaine-adrenaline could increase whereas stem bark and fruit extract could decrease respiratory rate, respectively. Highest duration of anaesthesia was observed in stem- bark extract anaesthetized dogs followed by fruit extract treated group in comparison with lignocaine-adrenaline and lignocaine treated groups. Time of onset of anaesthesia was longest in fruit extract treated group and shortest in lignocaine and lignocaine-adrenaline treated groups respectively. Lignocaine and lignocaine/adrenaline increased and decreased haematological parameters, respectively. Lignocaine, lignocaine-adrenaline and the extracts altered biochemical parameters. Hence, <i>Annona muricata</i> could serve as potent local anaesthetic agent.</p></div>\",\"PeriodicalId\":7613,\"journal\":{\"name\":\"Advances in Traditional Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2022-07-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in Traditional Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13596-022-00655-1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Traditional Medicine","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1007/s13596-022-00655-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Comparative local anaesthetic activity of lignocaine, lignocaine-adrenaline and water extracts of Annona muricata during castration in dogs
Lignocaine is a local anaesthetic used in castration of dogs. However, lignocaine is sometimes combined with adrenaline in order to prolong the anaesthetic effect. Either lignocaine or lignocaine-adrenaline combination is associated with toxicity effects. Hence, anaesthetic potentials of lignocaine, lignocaine-adrenaline, fruit and stem-bark aqueous extract of Annona muricata were comparatively studied during castration in Nigerian indigenous dogs. Twelve adult dogs of about 1.00 ± 0.00-year-old and weighing 8.8 ± 0.4 kg divided into four groups of three each were used. The four groups were administered 2% lignocaine, lignocaine-adrenaline, fruit and stem-bark aqueous extracts each, at a dose of, 7.5 mg/kg each, by infiltration on the scrotal sac. After loss of sensation, ochidectomy was carried out. Time of onset and duration of anaesthesia were significantly higher (p < 0.05) in stem bark and fruit extract groups as compared to lignocaine and lignocaine-adrenaline groups. More so duration of anaesthesia was higher in lignocaine-adrenaline as compared to adrenaline. The findings have shown that lignocaine and lignocaine-adrenaline could increase whereas stem bark and fruit extract could decrease respiratory rate, respectively. Highest duration of anaesthesia was observed in stem- bark extract anaesthetized dogs followed by fruit extract treated group in comparison with lignocaine-adrenaline and lignocaine treated groups. Time of onset of anaesthesia was longest in fruit extract treated group and shortest in lignocaine and lignocaine-adrenaline treated groups respectively. Lignocaine and lignocaine/adrenaline increased and decreased haematological parameters, respectively. Lignocaine, lignocaine-adrenaline and the extracts altered biochemical parameters. Hence, Annona muricata could serve as potent local anaesthetic agent.
期刊介绍:
Advances in Traditional Medicine (ADTM) is an international and peer-reviewed journal and publishes a variety of articles including original researches, reviews, short communications, and case-reports. ADTM aims to bridging the gap between Traditional knowledge and medical advances. The journal focuses on publishing valid, relevant, and rigorous experimental research and clinical applications of Traditidnal Medicine as well as medical classics. At the same time, the journal is devoted to communication among basic researcher and medical clinician interested in the advancement of Traditional Medicine. Topics covered by the journal are: Medical Classics & History; Biomedical Research; Pharmacology & Toxicology of Natural Products; Acupuncture & Moxibustion; Sasang Constitutional Medicine; Diagnostics and Instrumental Development; Clinical Research. ADTM is published four times yearly. The publication date of this journal is 30th March, June, September, and December.