The diagnostic value of detection of high-risk HPV in differentiating primary bladder cancer versus uterine cervical cancer involving bladder - A case report

Uterine cervical cancer can invade the urinary bladder at an advanced stage. Distinguishing between primary urothelial carcinoma and secondary carcinoma involving the bladder is extremely important because these two clinical settings have completely different management and prognosis. It can be very challenging for pathologists to determine the tumor origin, since the carcinomas in bladder and cervix have overlapping histological features and immunohistochemical profiles. Here we report a case of cervical carcinoma involving the urinary bladder in a woman with a remote history of cervical carcinoma. The diagnosis was confirmed by the aid of molecular detection of high-risk human papillomavirus 16/18 (HPV16/18).