稳定型冠心病合并非酒精性脂肪肝患者systemiС低强度炎症的特点

Yu. I. Manusha, Y. Kazakov, Т. Trybrat, K. Ischeykin, Юрій Михайлович Казаков, Юлія Іванівна Мануша, Тетяна Анатоліївна Трибрат, Костянтин Євгенович Іщейкін
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引用次数: 0

摘要

目前,冠心病和非酒精性脂肪肝是乌克兰乃至世界的重大问题。肝功能障碍可促进冠心病的发生和发展。动脉粥样硬化的起始过程是一种低强度的慢性全身性炎症。这种关于动脉粥样硬化发展的观点是在过去二十年中形成的。本研究的目的是研究冠心病合并非酒精性脂肪性肝病患者低强度全身性炎症的特征/特点。这项研究涉及135名冠心病患者:稳定型心绞痛、I-II功能级、0-I心力衰竭合并非酒精性脂肪性肝病和30名健康人。我们检测了患者血液中细胞因子-TNFα和IL-10的水平,急性期反应物和凝血因子的含量,内皮功能障碍的标志是循环内皮微粒(CEM) CD32+ CD40+的量和单核外周血中IkBα基因NF-kB的表达水平。我们研究了单核细胞中IkBα mRNA基因的表达水平,反映了稳定型冠心病和冠心病合并NAFLD患者NF-kB转录活性水平显示,与稳定型冠心病患者相比,稳定型冠心病患者IkBα mRNA基因的表达显著增加88.5%。CEM CD32+ CD40+对内皮功能状态的分析表明,冠心病组和冠心病合并NAFLD组存在内皮功能障碍。比较冠心病合并NAFLD患者低强度全身炎症指标和内皮功能障碍标志物,合并合并NAFLD患者TNFα、急性期反应物、凝血纤维蛋白原因子及mRNA IkBα基因表达均显著升高,提示冠心病合并NAFLD患者较冠心病组整体低强度全身炎症水平升高。
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PECULIARITIES OF SYSTEMIС INFLAMMATION OF LOW INTENSITY IN PATIENTS WITH STABLE CORONARY HEART DISEASE CONCURRENT WITH NON-ALCOHOLIC FATTY LIVER DISEASE
Nowadays, coronary heart disease and non-alchoholic fatty liver disease are significant problems in Ukraine and world. Functional liver disorders potentiate the development and progression of CHD. The initiation process of atherosclerosis is a chronic systemic inflammation of low intensity. This view on atherosclerosis development has been forming during the past two decades. The aim of the research was to study the features/characteristics of systemic inflammation of low intensity in patients with coronary heart disease in combination with non-alcoholic fatty liver disease. The research involved 135 people with CHD: stable angina, I-II functional class, 0-I heart failure in combination with non-alcoholic fatty liver disease and 30 healthy individuals. We examined patients in terms of blood levels of cytokines -TNFα and IL-10, the content of the acute phase reactant and the coagulation factor, the marker of endothelial dysfunction is the amount of circulating endothelial microparticles (CEM) CD32+ CD40+ and the expression level of IkBα gene NF-kB in mononuclear peripheral blood. We studied the level of expression of the mRNA gene of IkBα in mononuclear cells, which reflects the level of transcriptional activity of NF-kB in patients with stable coronary artery disease and CHD in combination with NAFLD showed a significant increase in the expression of the mRNA gene of IkBα by 88.5% compared to patients with stable stable coronary heart disease. The analysis of the functional state of the endothelium with help of CEM CD32+ CD40+ has shown the presence of endothelial dysfunction in the groups of patients with CHD and CHD in combination with of NAFLD. Comparison of the indicators of systemic inflammation of low intensity and marker of endothelial dysfunction in patients with CHD in combination with NAFLD revealed a significant increase of TNFα, acute phase reactant and coagulation fibrinogen factor and expression of the mRNA IkBα gene in patients with comorbidity, indicating an increase the level of systemic inflammation of low intensity in patients with CHD in combination with NAFLD as compared with the group of patients with CHD.
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