癌症——对抗代谢综合征的务实转变?

IF 3.1 Q2 ONCOLOGY Oncology Reviews Pub Date : 2023-02-15 DOI:10.3389/or.2023.10573
John A. Claras
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引用次数: 0

摘要

癌症和代谢性疾病已成为当今世界普遍存在的健康风险。癌症是一组复杂的疾病,有很多定义。大约15%的癌症是由感染引起的,10%的癌症带有遗传负担。其余70%-75%的癌症与多种过程有关,通常与代谢综合征和慢性炎症有关。本文综述了代谢功能障碍和慢性炎症在癌症发展中的作用。我提出了一个新的开关概念,在这个概念中,我们的智能身体首先使用其复杂的子系统和传感器,务实地预测和对抗代谢功能障碍,将其作为“最直接和最可怕的威胁”,同时暂时接受癌症作为一种状态,在任何其他情况下都被认为是有害的,并利用癌症作为降低血糖水平的额外工具。一旦代谢功能障碍得到解决,这种转换就会被逆转,癌症的生长就会受到损害。
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Cancer—A Pragmatic Switch to Combat Metabolic Syndrome?
Both cancer and metabolic disease have become the prevalent health risks in modern societies worldwide. Cancer is a complex set of illnesses with many definitions. About 15% of cancers are caused by infections, and 10% carry a hereditary burden. The remaining 70%–75% cancers are associated with a variety of processes, often associated with metabolic syndrome and chronic inflammation. This review examines the role of metabolic dysfunction and chronic inflammation in cancer development. I propose a novel concept of a switch, in which our intelligent body uses its sophisticated set of subsystems and sensors to pragmatically anticipate and combat metabolic dysfunction as its’ most direct and dire threat first, while temporarily accepting cancer as a state that in any other circumstances would be considered detrimental, and utilizing cancer as an additional tool to lower glucose levels. Once metabolic dysfunction has been resolved this switch is reversed, and cancer growth will be impaired.
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来源期刊
Oncology Reviews
Oncology Reviews ONCOLOGY-
CiteScore
6.30
自引率
0.00%
发文量
9
审稿时长
9 weeks
期刊介绍: Oncology Reviews is a quarterly peer-reviewed, international journal that publishes authoritative state-of-the-art reviews on preclinical and clinical aspects of oncology. The journal will provide up-to-date information on the latest achievements in different fields of oncology for both practising clinicians and basic researchers. Oncology Reviews aims at being international in scope and readership, as reflected also by its Editorial Board, gathering the world leading experts in both pre-clinical research and everyday clinical practice. The journal is open for publication of supplements, monothematic issues and for publishing abstracts of scientific meetings; conditions can be obtained from the Editor-in-Chief or the publisher.
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