Nanomaterial-Based Surface Plasmon Resonance Sensing Chip for Detection of Skin and Breast Cancer

Today’s advancements in technology in modern-day life have substantially raised the significance of surface plasmon resonance (SPR) sensors. In order to enhance the sensor’s performance, experts are now focused on developing a SPR biomedical sensor that integrates a prism with a thin nanocomposite layer. The proposed SPR biosensor has been built with silver, BaTiO₃, and 2D layering of materials (MoSe₂/WS₂) for the purpose to identifying skin and breast cancer cells. In this analysis, the attenuated total reflection (ATR) technique of SPR is used for the detection of skin cancer (basal cell) and breast cancer cells (MM-231 and MCF-7) to evaluate the results. It is being observed that by utilizing two metallic silver coatings with a thickness of 50 nm and 10 nm. The effectiveness of the device can be improved with two layers of WS₂ (each of 0.5 nm) and two layers of BaTiO₃ (each of 5 nm); the highest sensitivity can be achieved in the case of skin cancer. The numerical findings show that the basal cell’s highest sensitivity is 253.5 (°/RIU) and breast (MM-231 and MCF-7) cancer cells are 309.2857°/RIU and 295.71°/RIU. The figure of merit (FoM), detection accuracy (DA), and signal-to-noise ratio (SNR) are 146.11 (RIU⁻¹), 0.576 (degree⁻¹), and 2.922, respectively, for basal cells, and for breast cancer, 255.66 (RIU⁻¹), 0.829 (degree⁻¹), and 3.59 are realized. Lastly, the numerical outcomes derived in this manuscript revealed a high degree of sensitivity and FoM compared to those of previous research studies.