大麻二酚在胶质母细胞瘤治疗中的应用

IF 0.4 4区 医学 Q4 PHARMACOLOGY & PHARMACY Acta poloniae pharmaceutica Pub Date : 2023-06-29 DOI:10.32383/appdr/163414
A. Rybarczyk, A. Majchrzak-Celińska, V. Krajka-Kuźniak
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引用次数: 1

摘要

多形性胶质母细胞瘤(GBM)是一种高度星形细胞瘤,是一种无法治愈的脑肿瘤,与遗传异质性和信号通路失调有关。内源性大麻素系统的改变已经在GBM细胞中得到证实,影响其关键元素的物质可能潜在地抑制肿瘤进展。临床前模型表明,CBD通过抑制细胞增殖、迁移和侵袭来抑制GBM肿瘤的生长,同时也促进肿瘤细胞的自噬和凋亡。此外,临床试验表明大麻素治疗对GBM患者的生存具有安全性和积极的结果。然而,迫切需要更多的大样本量的人体临床试验来实施大麻素,包括CBD,用于标准的GBM治疗。
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The application of cannabidiol in the treatment of glioblastoma
Glioblastoma multiforme (GBM), a high-grade astrocytoma, is an incurable brain tumor associated with genetic heterogeneity and dysregulated signaling pathways. As alternations of the endocannabinoid system have been demonstrated in GBM cells, the substances affecting its key elements may potentially inhibit tumor progression. Preclinical models indicate that CBD inhibits GBM tumor growth by inhibiting cellular proliferation, migration, and invasion but also promotes autophagy and apoptosis of tumor cells. Moreover, clinical trials indicate the safety and positive results regarding the survival of GBM patients upon cannabinoids treatment. Nevertheless, more human clinical trials with large sample sizes are urgently needed to implement cannabinoids, including CBD, into standard GBM treatment.
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
74
审稿时长
6-12 weeks
期刊介绍: The international journal of the Polish Pharmaceutical Society is published in 6 issues a year. The journal offers Open Access publication of original research papers, short communications and reviews written in English, in all areas of pharmaceutical sciences. The following areas of pharmaceutical sciences are covered: Analysis, Biopharmacy, Drug Biochemistry, Drug Synthesis, Natural Drugs, Pharmaceutical Technology, Pharmacology and General. A bimonthly appearing in English since 1994, which continues “Acta Poloniae Pharmaceutica”, whose first issue appeared in December 1937. The war halted the activity of the journal’s creators. Issuance of “Acta Poloniae Pharmaceutica” was resumed in 1947. From 1947 the journal appeared irregularly, initially as a quarterly, then a bimonthly. In the years 1963 – 1973 alongside the Polish version appeared the English edition of the journal. Starting from 1974 only works in English are published in the journal. Since 1995 the journal has been appearing very regularly in two-month intervals (six books a year). The journal publishes original works from all fields of pharmacy, summaries of postdoctoral dissertations and laboratory notes.
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