铁下垂的营养与代谢控制。

IF 12.6 2区 医学 Q1 NUTRITION & DIETETICS Annual review of nutrition Pub Date : 2022-06-01 DOI:10.1146/annurev-nutr-062320-114541
Eikan Mishima, M. Conrad
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引用次数: 21

摘要

脱铁症是一种调节性细胞死亡,其特征是抗氧化防御系统破坏和/或细胞代谢失衡导致细胞膜脂质过氧化过度。脱铁症与其他形式的调节性细胞死亡的不同之处在于,几种代谢途径和营养方面,包括内源性抗氧化剂(如辅酶Q10、维生素E和二/四氢生物蝶呤)、铁处理、能量传感、硒利用、氨基酸和脂肪酸,直接调节细胞对脂质过氧化和脱铁症的敏感性。由于脱铁症的特征已被记录在多种疾病中,包括神经退行性变、急性器官损伤和耐治疗肿瘤,使用药理学工具或代谢重编程调节脱铁症在治疗脱铁症相关疾病和癌症治疗中具有巨大潜力。因此,这篇综述的重点是代谢和营养线索对脱铁性贫血的调节,并讨论了通过靶向脱铁性肾病进行营养干预治疗的潜力。《营养年度评论》第42卷预计最终在线出版日期为2022年8月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
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Nutritional and Metabolic Control of Ferroptosis.
Ferroptosis is a type of regulated cell death characterized by an excessive lipid peroxidation of cellular membranes caused by the disruption of the antioxidant defense system and/or an imbalanced cellular metabolism. Ferroptosis differentiates from other forms of regulated cell death in that several metabolic pathways and nutritional aspects, including endogenous antioxidants (such as coenzyme Q10, vitamin E, and di/tetrahydrobiopterin), iron handling, energy sensing, selenium utilization, amino acids, and fatty acids, directly regulate the cells' sensitivity to lipid peroxidation and ferroptosis. As hallmarks of ferroptosis have been documented in a variety of diseases, including neurodegeneration, acute organ injury, and therapy-resistant tumors, the modulation of ferroptosis using pharmacological tools or by metabolic reprogramming holds great potential for the treatment of ferroptosis-associated diseases and cancer therapy. Hence, this review focuses on the regulation of ferroptosis by metabolic and nutritional cues and discusses the potential of nutritional interventions for therapy by targeting ferroptosis. Expected final online publication date for the Annual Review of Nutrition, Volume 42 is August 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
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来源期刊
Annual review of nutrition
Annual review of nutrition 医学-营养学
CiteScore
15.80
自引率
0.00%
发文量
19
期刊介绍: Annual Review of Nutrition Publication History:In publication since 1981 Scope:Covers significant developments in the field of nutrition Topics Covered Include: Energy metabolism; Carbohydrates; Lipids; Proteins and amino acids; Vitamins; Minerals; Nutrient transport and function; Metabolic regulation; Nutritional genomics; Molecular and cell biology; Clinical nutrition; Comparative nutrition; Nutritional anthropology; Nutritional toxicology; Nutritional microbiology; Epidemiology; Public health nutrition
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