Deactivated Phospholipids in an Osteoarthritic Joints: Lost Surface Lubricity

This study is designed to determine phospholipids (PLs) dysfunction on cartilage surface and in synovial fluid (SF) in an osteoarthritic (OA) joints. The (PLs) in (SF) were measured for normal samples, with early eOA and late lOA stages of (OA) and rheumatoid arthritis (RA). During cartilage inflammation enzymatically activated β2-Glycoprotein I was transformed into antibody conformation (see Fig. 3). Deactivated PLs molecule lost ability to form bilayers and liposomes content in synovial fluid (SF) in osteoporotic joints is significantly higher (2-3 times) above the normal concentration of PLs. Additionally, the osteoporotic cartilage surface showed surface lubricity (f) 0.015 about three times higher, compared to the normal cartilage.